Senior Scientist II – ADC Reaction Engineer

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          "text": "<p>R&amp;D Process Engineering, a part of AbbVie’s Development Sciences organization in Synthetic Molecules CMC (Chemistry, Manufacturing, and Controls), is responsible for designing and developing scalable processes to make drug substances and drug products, including small molecules and antibody drug conjugates (ADCs), throughout pre-clinical and clinical development stages. &#xa0;Responsibilities include synthetic route design, process definition, scale-up, and tech transfer for wide varieties of therapeutics and technologies to meet evolving pipeline demand.&#xa0; The R&amp;D Process Engineering team also partners with Biologics CMC Development and Aesthetics R&amp;D functions to provide active engineering support to enable robust process scale-up and manufacturing of biologics drug substances and drug products including toxins, lipid nanoparticles (LNP’s), and cosmetic active ingredients (CAIs). We contribute to the development of innovative engineering technologies and create valuable intellectual property through the composition of matter, chemical processes, and technologies resulting in cost-effective commercial manufacturing processes. We support the development of the supply chain for pipeline molecules and help prepare and defend CMC regulatory content.</p><p>&#xa0;</p><p>Chemical Engineers within Process Engineering support pipeline projects through all phases of development. Early in development, engineers focus on establishing an enabling process that can be scaled-up successfully. In the later stages of development, engineers optimize the drug substance and drug product processes and lead manufacturing campaigns. Engineers also work cross-functionally to transfer the optimized process to manufacturing sites, develop control strategies, and prepare reports to support regulatory filings.</p><p>&#xa0;</p><p><strong>Role Overview</strong></p><p>The successful engineering candidate will play a key role in the R&amp;D Process Engineering function.&#xa0;The core deliverable of R&amp;D Process Engineering is to develop robust manufacturing processes and advance innovative technologies using strong engineering fundamentals.&#xa0; Key requirements for this role include a demonstrated capability to model antibody drug conjugate kinetics and mechanisms, experience with drug linker and drug substance process design, development of flow chemistry reactor platforms, including in use for ADC’s, experience with highly potent compound handling, leadership of novel reactor configuration development (e.g., photochemistry, electrochemistry, membrane reactors, etc.), and expertise in computational fluid dynamics to support reactor design and tech transfer.&#xa0; The candidate must have prior reaction development and scale-up experience with demonstrated examples of scale up of ADC processes, including reaction and purification.</p><p>The candidate is expected to lead the identification and development of novel approaches and technologies to enhance process development efficiency and commercialization throughout existing and new modalities in Development Sciences, including small molecules, ADC’s, lipid nano-particles, and toxins. The candidate must exhibit a collaborative nature in identifying process challenges on a wide range of projects in the Drug Substance and Drug product space, take part in a cross-functional team to deliver specific project needs, and take on a leadership role in developing and implementing solutions.</p><p>&#xa0;&#xa0;</p><p><strong>Key Responsibilities:</strong></p><ul><li>Develop robust manufacturing processes, supporting assets through all phases of development.</li><li>Participate in and/or lead project teams towards development and characterization of new small and large molecule assets. Establish, communicate, and execute research plans.</li><li>Develop commercial ready manufacturing processes in the laboratory and demonstrate the processes in the pilot plant.</li><li>Set project strategies, define project responsibilities and timelines, and provide leadership in a matrixed team setting.</li><li>Address&#xa0;challenging problems with chemical and biochemical reactions, separations, and/or isolations using demonstrated expertise in reaction kinetics, transport phenomena, and mathematical modeling.</li><li>Develop and apply process analytical technologies and data-rich experimentation tools to build appropriate reaction and process understanding via model-guided experimentation.</li><li>Build data driven and knowledge driven models to facilitate successful scale-up and tech transfer.</li><li>Author and/or review technical documents summarizing process development efforts and contribute to regulatory filings.</li><li>Exhibit&#xa0;a collaborative nature in identifying process challenges on a wide range of projects and communicate findings and recommendations effectively&#xa0;by multi-disciplinary interactions with organic chemists, analytical chemists, process development engineers, pilot plant engineers, drug product development scientists, program managers, and regulatory affairs specialists.&#xa0;</li><li>Author publications and present at scientific conferences.&#xa0;</li></ul>",
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          "text": "<ul><li>BS, MS, or PhD in Chemical/Bio Engineering or a related field and 12+ (BS), 10+ (MS), or 4+ (PhD) years of relevant industrial experience.</li><li>Candidates are expected to have a strong background in chemical engineering and the proven ability to demonstrate their skills in this field.</li><li>Demonstrated capability to model antibody drug conjugate kinetics and mechanisms</li><li>Experience with drug linker and drug substance process design, including tech transfer and scale-up</li><li>Development of flow chemistry reactor platforms, including in use for ADC’s</li><li>Experience with highly potent compound handling</li><li>Leadership of novel reactor configuration development (e.g., photochemistry, electrochemistry, membrane reactors, etc.)</li><li>Expertise in computational fluid dynamics to support reactor design and tech transfer</li><li>The candidate is expected to demonstrate the ability to solve difficult technical problems and champion new technologies to achieve project goals.</li><li>The candidate is required to be a strong team player and demonstrate scientific leadership, possessing effective oral and written communication skills for facilitating collaborations and leading cross-functional process development teams.</li></ul>",
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          "text": "<p><strong>About AbbVie</strong></p><p>AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at&#xa0;<a href=\"http://www.abbvie.com/\" rel=\"noopener noreferrer\">www.abbvie.com</a>. Follow @abbvie on&#xa0;<a href=\"https://www.linkedin.com/company/abbvie/\" rel=\"noopener noreferrer\">LinkedIn,</a>&#xa0;<a href=\"https://www.facebook.com/AbbVieGlobal/\" rel=\"noopener noreferrer\">Facebook</a>,&#xa0;<a href=\"https://www.instagram.com/abbvie/\" rel=\"noopener noreferrer\">Instagram</a>,&#xa0;<a href=\"https://twitter.com/abbvie\" rel=\"noopener noreferrer\">X</a>&#xa0;and&#xa0;<a href=\"https://www.youtube.com/user/AbbVie\" rel=\"noopener noreferrer\">YouTube.</a></p>",
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          "text": "<p>Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or&#xa0;local law:&#xa0;​</p><ul><li><p>The compensation range described below is the range of possible base pay compensation that the Company&#xa0;believes in&#xa0;good faith it will pay for this role at the time&#xa0;of this posting based on the job grade for this position.&#xa0;Individual&#xa0;compensation paid within this range will depend on many factors including geographic location, and&#xa0;we&#xa0;may&#xa0;ultimately&#xa0;pay&#xa0;more or less than the posted range. This range may be&#xa0;modified&#xa0;in the&#xa0;future.&#xa0;​</p></li><li><p>We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),&#xa0;medical/dental/vision&#xa0;insurance and 401(k) to eligible&#xa0;employees.​</p></li><li><p>This job is eligible to&#xa0;participate&#xa0;in our long-term incentive&#xa0;programs.&#xa0;​</p></li></ul><p>Note: No amount of pay&#xa0;is considered to be&#xa0;wages or compensation until such amount is earned, vested, and&#xa0;determinable.&#xa0;The amount and availability of any bonus,&#xa0;commission, incentive, benefits, or any other form of&#xa0;compensation and benefits&#xa0;that are allocable to a particular employee&#xa0;remains&#xa0;in the Company's sole and&#xa0;absolute&#xa0;discretion unless and until paid and&#xa0;may be&#xa0;modified&#xa0;at the Company’s sole and absolute discretion, consistent with&#xa0;applicable law.​</p><div sr-tagline=\"\"></div><p>AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.&#xa0;</p><p>US &amp; Puerto Rico only - to learn more, visit&#xa0;<a href=\"https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html\" rel=\"noopener noreferrer\">https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html</a></p><p>US &amp; Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:</p><p><a href=\"https://www.abbvie.com/join-us/reasonable-accommodations.html\" rel=\"noopener noreferrer\">https://www.abbvie.com/join-us/reasonable-accommodations.html</a></p>",
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