Postdoctoral Fellow, Live Tissue Omics

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere. The Team The Biohub is a group of nonprofit research institutes that bring together scientists, engineers, and physicians with the goal of pursuing grand scientific challenges on 10- to 15-year time horizons. The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies. Our Vision We pursue large scientific challenges that cannot be pursued in conventional environments We enable individual investigators to pursue their riskiest and most innovative ideas The technologies developed at the Biohub facilitate research by scientists and clinicians at our home institutions and beyond Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution. The Opportunity Biohub Chicago seeks outstanding early-career scientists and engineers to join its Quantitative Live Tissue Transcriptomics platform as a Postdoctoral Research Scholar in longitudinal and single-cell profiling. This role offers a unique opportunity to work hands-on in a generously funded, highly collaborative environment at the intersection of technology development, biology, and disease-focused discovery. Postdoctoral Research Scholars will be embedded in interdisciplinary teams developing and applying next-generation transcriptomic workflows for non-destructive, time-resolved measurements from living cells and tissues. A central focus of this role is understanding how dynamic gene expression and cell-to-cell transcriptional heterogeneity shape the behavior of immune-competent organoid and ex vivo systems. The successful candidate will leverage emerging live-sampling technologies to interrogate cellular dynamics, immune–tissue interactions, and emergent phenotypes that are inaccessible with static, endpoint approaches. This position provides strong mentorship alongside meaningful scientific independence within a team-science model that emphasizes collaboration across experimental, computational, and engineering domains. Projects align with the Biohub's mission to uncover fundamental disease mechanisms and to develop transformative measurement technologies that accelerate biomedical research. Biohub Chicago is deeply committed to training scientists for impactful careers in academia, industry, and beyond. What You'll Do Design and execute longitudinal transcriptomics experiments to investigate dynamic gene expression and transcriptional heterogeneity in immune-competent organoid systems. Develop, optimize, and apply advanced RNA profiling workflows for non-destructive, time-resolved sampling from living cells and tissues, including method development, benchmarking, and quality control. Collaborate closely with interdisciplinary teams spanning tissue engineering, immunology, computation, and instrumentation to build and interrogate increasingly complex immune-organoid models. Analyze and interpret large-scale transcriptomics and lineage barcoding datasets using state-of-the-art computational pipelines, and communicate results clearly through figures, presentations, and internal discussions. Disseminate research outputs through high-impact publications, preprints, and open scientific resources, contributing to a culture of open and collaborative science. What You'll Bring PhD in genomics, bioengineering, quantitative biology, systems immunology, computational biology, or a related quantitative life-science field. Experience with quantitative molecular and cell biology techniques and high-throughput profiling. Demonstrated expertise in quantitative interpretation of complex, high-dimensional datasets. Strong record of scientific productivity, creativity, and collaborative problem-solving in interdisciplinary research environments. Motivation to pursue innovative, independent research aligned with the Biohub’s mission and to thrive in a hands-on, team-science culture. [Nice to have] Experience with sequencing platforms and transcriptomics workflows (e.g., RNA-seq, single-cell RNA-seq, or spatial transcriptomics). [Nice to have] Experience with RNA engineering, molecular barcoding, or novel nucleic acid technologies. [Nice to have] Background in immune cell biology, immune–tissue interactions, or organoid model systems. Compensation The Chicago, IL base pay for a new hire in this role is $84,150. This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role. Better Together As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. Provides a generous employer match on employee 401(k) contributions to support planning for the future. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. #LI-Onsite

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