Protein Scientist

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    "description": "<p><span style=\"font-weight: bold\">The Role: Protein Scientist </span></p>\n<p>T-Cypher Bio is an early-stage, innovative biotechnology company aiming to unlock an expansive target space to build a pipeline of novel, T-cell receptor (TCR)-based therapeutics. We are seeking a highly motivated TCR engineer or protein scientist with a strong background in protein production and characterisation to advance our bispecific engineering pipeline.</p>\n<p> </p>\n<p><span style=\"font-weight: bold\">What you will do </span></p>\n<p>The primary focus of this role will be to execute experiments for the screening &amp; characterisation of soluble TCR proteins. The ideal candidate should have hands-on experience with soluble protein production as well as demonstrate a strong understanding of protein engineering, protein affinity measurement by SPR or BLI, and molecular biology methods.</p>\n<p><br></p>\n<p><span style=\"font-weight: bold\">Key Responsibilities</span></p>\n<ul>\n<li>Produce soluble TCR proteins with improved properties using various protein expression systems and purification methods</li>\n<li>Characterise TCR proteins using various biochemical and biophysical techniques such as SDS-PAGE, HPLC, and biophysical affinity measurement methods such as differential scanning fluorimetry (DSF), surface plasmon resonance (SPR) or biolayer interferometry (BLI)</li>\n<li>Develop and implement high throughput key assays to progress our pipeline activities</li>\n<li>Develop and optimise TCR expression and purification protocols</li>\n<li>Influence group and project meetings, offering insights and expertise to advance research projects</li>\n<li>Prioritisation of personal workloads and coordination of scientific workstreams and processes</li>\n<li>Analyse and record experimental results and communicate findings to the team and to management</li>\n<li>Maintain and implement good laboratory practices, including accurate laboratory notebook systems, instrument and reagent maintenance, and personnel safety precautions<br><br></li>\n</ul>\n<p><span style=\"font-weight: bold\">To be successful you will need</span></p>\n<p> </p>\n<ul>\n<li>A Masters in protein sciences, immunology, molecular biology, or related field with at least 2 years relevant industrial experience or a PhD with relevant experience as detailed below.</li>\n<li>Hands on experience in biochemical techniques for the characterisation and affinity measurement of proteins e.g. SDS-PAGE gel analysis, HPLC, western blot, DSF, and surface plasmon resonance (Biacore) or biolayer interferometry (Octet)</li>\n<li>Expertise in expression of recombinant proteins in mammalian cells (e.g. CHO, HEK)</li>\n<li>Expertise in soluble TCR/protein production</li>\n<li>Experience with protein purification using AKTA FPLC systems</li>\n<li>Ability to design and generate protein constructs and formats</li>\n<li>Analysing &amp; presenting results in a concise and accurate manner to the wider team</li>\n</ul>\n<ul>\n<li>Ability to adapt to multiple roles in a matrixed, fast-paced and evolving company</li>\n<li>Enjoy working towards challenging goals in a fast-moving environment</li>\n<li>Ability to follow and write protocols and SOPs</li>\n<li>Knowledge of health and safety regulations in a laboratory environment</li>\n</ul>\n<ul>\n<li>Strong organisational and communication skills (both written and verbal)</li>\n</ul>\n<p> </p>\n<p><span style=\"font-weight: bold\">What we offer</span></p>\n<p> </p>\n<p>Competitive salary and benefits commensurate with qualifications and experience.</p>\n<p>Modern, well-equipped office and laboratory facilities on Abingdon Science Park (from June 2026).</p>\n<p>Training and development opportunities in line with the company’s goals and growth plans.</p>\n<p>An exciting opportunity to help establish an early-stage biotech with ambitions to impact patients’ lives.</p>\n<p> </p>\n<p><span style=\"font-weight: bold\">How to apply</span></p>\n<p> </p>\n<p>Applications will be evaluated in the order that they are received, you are encouraged to apply as soon as possible.</p>\n<p>Applications will close once the position is filled.</p>",
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