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HomeCompaniesAbbviePrincipal Research Scientist I, siRNA Synthesis & Analytical Development

Principal Research Scientist I, siRNA Synthesis & Analytical Development

Abbvie · Worcester, MA, United States · Active · $124,500–$236,500 / year · SmartRecruiters

Job facts

FieldValue
CompanyAbbvie
TitlePrincipal Research Scientist I, siRNA Synthesis & Analytical Development
Normalized title-
Department / teamResearch
LocationWorcester, MA, United States
Work model-
Employment typeFull Time
Salary$124,500–$236,500 / year
Statusactive
ATS providerSmartRecruiters
Posted / first seen2026-06-05 / 2026-06-06
Changed / last seen2026-06-06 / 2026-06-06

Related slices

PageWhat it containsOpen
Company jobsActive postings from Abbvie.Open
Company breakdownsRole, location, ATS, and work model facets for this company.Open
ATS provider jobsActive postings observed through SmartRecruiters.Open
Provider filtered searchThe same provider as a filtered job collection.Open
City jobsActive postings in Worcester.Open
Department jobsActive postings in Research.Open
Lifecycle eventsOpen, update, close, and reopen events for this posting.Open
Original postingCanonical source or apply URL captured from the ATS.Open

Linked records

CompanyAbbvie
Source78fbf4b3-4225-45c8-b041-228a3314c7ee
ATS providerSmartRecruiters

Description

About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at  www.abbvie.com . Follow @abbvie on  LinkedIn,   Facebook ,  Instagram ,  X  and  YouTube. The Biotherapeutics and Genetic Medicine (BGM) department at AbbVie is seeking a motivated Principal Research Scientist to join the growing siRNA team. In this role, you will work with the genetic medicine teams to establish siRNA synthesis, purification, and analytical capabilities. You will serve as a subject matter expert in oligonucleotide chemistry and siRNA production, with responsibility for generating high-quality siRNA materials to advance genetic medicine studies. Responsibilities: Lead the siRNA synthesis platform to support various stages of siRNA studies.  Oversee solid-phase oligonucleotide synthesis, deprotection, purification, desalting, and analytical characterization of siRNA.  Troubleshoot synthesis, purification, and analytical challenges to improve yield, purity, and scalability.  Partner with cross-functional teams, including the siRNA screening team, the antibody conjugation group, and CMC, to support platform and project objectives.  Ensure rigorous documentation, data integrity, and compliance with internal quality standards.  Track and evaluate emerging technologies and best practices in oligonucleotide and RNA-based therapeutics.  Manage and develop a team of 2–3 scientists to support program goals and deliver high-quality siRNA materials on time. BS, MS, or PhD in chemistry, chemical biology, biochemistry, or a related field, with typically 6+ (PhD), 12+ (MS), or 14+ (BS) years of experience in biotech or pharma. Demonstrated expertise in siRNA synthesis, purification, and characterization. Strong knowledge of oligonucleotide chemistry, RNA chemistry, conjugation chemistry, and analytical techniques such as HPLC, LC-MS, and UV spectroscopy. Demonstrated ability to independently address complex technical problems and drive projects forward. Excellent communication, collaboration, and organizational skills. Strong track record of presenting complex scientific data to internal and external stakeholders. Prior people management experience is a plus. Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​ The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​ We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​ This job is eligible to participate in our short-term and long-term incentive programs. ​ Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.​ AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit  https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

Full job record

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Providersmartrecruiters
Provider Job Key3743990013503219
TitlePrincipal Research Scientist I, siRNA Synthesis & Analytical Development
Normalized Title
Statusactive
Activeyes
Location TextWorcester, MA, United States
DepartmentResearch
Team
Employment Typefull_time
Workplace Type
Remote Policy
CountryUnited States
RegionMA
CityWorcester
Salary RawUSD 124500-236500 year
Salary Min124,500
Salary Max236,500
Salary CurrencyUSD
Salary Periodyear
Source URLhttps://jobs.smartrecruiters.com/AbbVie/3743990013503219-principal-research-scientist-i-sirna-synthesis-analytical-development
Apply URLhttps://jobs.smartrecruiters.com/AbbVie/3743990013503219-principal-research-scientist-i-sirna-synthesis-analytical-development?oga=true
First Seen At2026-06-06 10:45:35Z
Last Seen At2026-06-06 10:45:35Z
Last Checked At2026-06-06 10:45:35Z
Last Changed At2026-06-06 10:45:35Z
Inactive At
Source Posted At2026-06-05 21:04:11Z
Source Updated At
Raw Payload Uris3://job-postings-prod-raw-590183727216/raw/provider=smartrecruiters/board=abbvie/date=2026-06-06/2026-06-06T10-45-26-237Z-add6ce205f3d964e8bf0951cb095a328af3cd9fe0cba97e1cc24d417318dd120.json
Event Fields
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Parsed Structured
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Extensions
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Native Structured
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