Scientist II, Neurobiology Target Validation  and Drug Discovery

About Us Valo Health is a human-centric, AI-enabled biotechnology company working to make new drugs for patients faster. The company’s Opal Computational Platform transforms drug discovery and development through a unique combination of real-world data, AI, human translational models and predictive chemistry. Our talented team of biologists, chemists and engineers, armed with advanced AI/ML tools, work together to break down traditional R&D silos and accelerate the speed and scale of drug discovery and development. Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We embrace new ways of learning, solve complex problems and welcome diverse perspectives that can help us advance patient-centric innovation. Valo is headquartered in Lexington, MA, with additional offices in New York, NY and Tel Aviv, Israel. To learn more, visit  www.valohealth.com . About the Role... Valo   is looking for   a   Scientist   II   to   play a pivotal role in   wet-lab   target validation and assay development for neurodegenerative disease targets, with an initial focus on Parkinson’s disease,   that have been   identified   using   Valo’s   human-centric   Opal   computational   platform.    This role will also support drug discovery program goals including compound and biological mechanism of action and cellular efficacy model studies.  The Scientist II will have a passion for translating   human data insights into new therapies for complex neurodegenerative diseases.    The Scientist II will work cross-functionally with   subject matter experts,   computational scientists,   and   engineers in a team-based environment to bring forward novel and creative solutions to target validation.   Your work will build confidence in the translation of   candidate   drug   targets   to diseases of interest.   You will also develop assays to characterize and address specific questions related to drug development of selected targets As a key bench scientist, you will   execute experiments to   deliver   validation data packages,   and   present results   to   internal and external stakeholders. This work will be done with a high degree of reliability, efficiency, and accuracy to allow key decisions on Valo targets. What You’ll Do… Your primary areas of responsibility will be: Generate experimental plans   and execute at the bench to enable   validation of novel   therapeutic   targets, address biological questions related to target drug discovery, and inform compound mechanism of action Develop and build well controlled human   functional   cellular assays in neuronal, glia, and other CNS relevant cell types to enable characterization of novel drug targets Perform experiments and generate   data in   the laboratory   with a high degree of reliability, efficiency, and accuracy to support target validation projects. Work in collaboration with other Valo scientists to progress target validation and drug development aligned with company goals Generate data with high quality standards and   document   within an electronic lab   notebook Stay current on emerging   trends and advancements in the field What You Bring… A PhD in   Biological Sciences   or   a   related field   with 2+ years   of   experience   (or   MS with   6+   years of experience   or a BS with   8+ years of experience) Expertise   in one or more of the following   areas: Neurobiology, Neurodegenerative disease, Parkison’s disease, cell biology Expertise in neuronal and neurodegenerative disease models (e.g. experience with PFF seeding models ( α –synuclein) and iPSC dopaminergic neuronal culture) Experience   in   human   in vitro   systems including primary cell culture and iPSC differentiation with neuronal cell types (neurons, microglia, astrocytes, co-culture systems), molecular biology,   and genetic manipulation (CRISPR, siRNA, overexpression systems) Experience in assay development with functional readouts (neuronal function, cell death assay, phagocytosis, cellular function and morphology, western blotting, ELISA, imaging (ICC/IF), qPCR/RT-qPCR) Strong   oral and written   communication,   presentation   and interpersonal skills Track record   of impactful scientific contributions as   demonstrated   by high impact publications Experience collaborating with multidisciplinary teams You May Also Bring… Experience in human  in  vitro systems including cell culture and functional assays related to Parkinson’s disease Experience with organoids or 2D/3D models Experience with barrier models looking at BBB structure and function Experience   working   in   in vivo/ex vivo   systems Experience in discovery stage preclinical drug discovery programs and with target validation projects MA Salary Range $123,250 — $145,000 USD Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Valo Health currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Valo Health's good faith estimate as of the date of publication and may be modified in the future. Please note: At this time, we are only able to consider candidates who currently have permanent US work authorization without the need for immediate or future sponsorship.

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