Lead Scientist - Novel Biomolecule Process Development

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    "description": "<p><span style=\"font-weight: bold\"><span><span>Who we are:    </span></span></span><span> </span></p>\n<p><br><span> </span></p>\n<p><span><span>Life, Reimagined     </span></span><span> <br></span><span><br></span><span> </span></p>\n<p><span><span>Constructive Bio is a VC-backed biotechnology startup based in Whittlesford, Cambridge. Our unique technology turns living cells into </span><span>biofactories</span><span>, creating sustainable new materials and therapeutics. With full control of the genetic sequence and code, we are exploring chemical space previously unreached by natural biology.   </span></span><span> <br></span><span><br></span><span> </span></p>\n<p><span><span>Constructive Bio is a spinout from Professor Jason Chin's laboratory at the MRC Laboratory of Molecular Biology in Cambridge. Learn more about the Chin lab achievements here: </span></span><a href=\"https://www2.mrc-lmb.cam.ac.uk/ccsb/jason-chin/\" target=\"_blank\" rel=\"noopener noreferrer\"><span><span>https://www2.mrc-lmb.cam.ac.uk/ccsb/jason-chin/</span></span></a><span><br></span><span> <br></span><span><br></span><span> </span></p>\n<p><span><span>We secured $58 million Series A fundraising. Read more here: </span></span><a href=\"https://www.constructive.bio/blog/news/constructive-bio-secures-58-million-in-series-a-financing\" target=\"_blank\" rel=\"noopener noreferrer\"><span><span>https://www.constructive.bio/blog/news/constructive-bio-secures-58-million-in-series-a-financing</span></span></a><span><br></span><span> </span></p>\n<p><span> </span></p>\n<p><span style=\"font-weight: bold\"><span><span>What </span><span>we’re</span><span> looking for</span><span>:</span></span></span><span> </span></p>\n<p><br></p>\n<p><span><span>We are l</span><span>ooking for a drive</span></span><span><span>n </span><span>L</span><span>ead</span><span> Scientist</span><span> – Novel Biomolecule Process Development</span><span> to</span></span><span><span> join our dynamic, collaborative group. This role will help us strengthen our route to commercialisation, enabling the scalable production of peptides and proteins with non-standard amino acids from our proprietary recoded strain of </span></span><span><span>E. coli</span></span><span><span>: </span></span><span><span>Syn61</span></span><span><span>. This platform has broad potential applications in new biologics therapies and beyond. Besides technical process development, the role requires ensuring communication between commercial and scientific teams. This position plays a significant part in our operations and the broader bioprocessing field, with great opportunities for role advancement.</span></span><span> </span></p>\n<p><span> </span></p>\n<p><span><span>The ideal candidate will have experience working with</span><span> </span><span>proteins, </span><span>peptides</span><span> and </span><span>diverse</span><span> chemistries</span><span> </span><span>with their</span><span> associated purification and anal</span><span>ytical </span><span>workflows</span><span>, </span><span>a</span><span> drive to progress innovative technologies, and an eagerness to learn.</span></span><span> </span></p>\n<p><span> </span></p>\n<p><span style=\"font-weight: bold\"><span><span>Responsibilities:</span></span></span><span> </span></p>\n<ul>\n<li><span><span>Develop, optimise, and scale-up</span><span> purification</span><span> and processing</span><span> strategies</span><span> for a range of </span><span>novel </span><span>recombinant </span><span>therapeutic </span><span>proteins</span><span> and</span><span> peptides</span><span>.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Utili</span><span>s</span><span>e various protein </span><span>analytical</span><span> techniques to assess quality</span><span> &amp; stability</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Plan and conduct experiments for process optimi</span><span>s</span><span>ation</span><span>, </span><span>characteri</span><span>s</span><span>ation</span><span> and quantification.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Support technology transfer to manufacturing and </span><span>assist</span><span> with process validation activities.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Contribute</span><span> to the </span><span>Technoeconomic assessment </span><span>of Bioprocesses</span><span>.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Stay current with the latest </span><span>peptide processing </span><span>techniques and technologies.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Ensure work is performed </span><span>in accordance with</span><span> safety and quality system procedures.</span></span><span> </span></li>\n</ul>\n<p><span> </span></p>\n<p><span style=\"font-weight: bold\"><span><span>Requirements</span><span>:</span></span></span><span> </span></p>\n<ul>\n<li><span><span>Minimum of a </span><span>Bachelor’s</span><span> degree in Biochemical Engineering, </span><span>Chemistry</span><span>, </span><span>Biochemistry,</span><span> medicinal chemistry</span><span>,</span><span> Biotechnology, or related field</span><span>, PhD level candidate preferred. </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Demonstrated project delivery in a relevant industrial setting. Experience in a GMP environment is a plus.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Experience developing</span><span> purification </span><span>and processing strategies for </span><span>protein and </span><span>peptide products, ideally for use in scalable production of therapeutic</span><span>s</span><span> </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Extensive experience in method development and characterization of Proteins &amp; ideally</span><span>,</span><span> small peptides via LC/MS and HPLC. </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Experience purifying recombinant proteins via various chromatographic methods using AKTA systems </span><span>(Primary capture, Ion-exchange, HIC). </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>A track record</span><span> of successfully transferring methods to external CRO/CMO suppliers for the execution of production methods and associated analytics at scale. </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>The ideal candidate will have extensive experience and knowledge in peptide chemistry</span><span>.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Strong problem-solving skills, good oral and written communication skills</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Ability to </span><span>operate</span><span> effectively within a matrix managed environment, effectively managing time across multiple projects </span></span><span> </span></li>\n</ul>\n<p><span style=\"font-weight: bold\"><span><span>Desirable Skills</span><span>:</span></span></span><span> </span></p>\n<ul>\n<li><span><span>Understanding or technical experience with Solid-phase</span><span> </span><span>peptide synthesis</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Experience developing methods for multiple step chemical modifications on peptides </span><span>or small molecules </span><span>for transfer to </span><span>scalable </span><span>operations. </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Experience with design of experiment (DOE) </span><span>methodology</span><span>.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Familiarity with Quality by Design (</span><span>QbD</span><span>) principles.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Familiarity with high cell density fermentation for </span></span><span><span>E. coli</span></span><span><span> in bench-top bioreactors.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Previous</span><span> experience with tech transfer and scale-up processes.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Understanding and experience interacting with the regulatory environment for recombinantly produced therapeutic proteins (CMC)</span></span><span> </span></li>\n</ul>\n<p><span> </span></p>\n<p><span style=\"font-weight: bold\"><span><span>What’s</span><span> in it for you? Why work at Constructive Bio?</span></span></span><span> </span></p>\n<p><span> </span></p>\n<ul>\n<li><span><span> We are a small but rapidly growing team, with a vision to become the programmable biomolecules company and push the boundaries of </span><span>what’s</span><span> possible between biology and chemistry. As an early joiner, you will have a unique opportunity to help shape our trajectory and make real impact from day one.    </span></span><span> </span></li>\n</ul>\n<p><br><span> <br></span><span style=\"font-weight: bold\"><span><span>We offer:   </span></span></span><span> </span></p>\n<p><br><span> </span></p>\n<ul>\n<li><span><span>Newly fitted dedicated site in Whittlesford near Cambridge – on-site parking and regular trains to Cambridge, </span><span>London</span><span> and Norwich   </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Competitive salary   </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Employee share option plan   </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>25 days holiday plus bank holidays   </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Private health insurance   </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Pension plan (matching up to 8%)   </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Collaborative and pioneering environment, at the leading edge of synthetic genomics and engineered translation   </span></span><span> </span></li>\n</ul>\n<p><span><br></span><span> <br></span><span><br></span><span> </span></p>\n<p><span><span>We want to build a team with trust and respect for each other and create a culture of collaboration, openness, curiosity, and scientific excellence.     </span></span><span> </span></p>\n<p><span><br></span><span> <br></span><span><span>We are built on three principles:    </span></span><span> <br></span><br><span> </span></p>\n<ul>\n<li><span style=\"font-weight: bold\"><span><span>We imagine: </span></span></span><span><span>We think big and plan our own path for success.     </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span style=\"font-weight: bold\"><span><span>We pioneer: </span></span></span><span><span>We </span><span>take action</span><span> and grow together as one to break moulds.    </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span style=\"font-weight: bold\"><span><span>We deliver: </span></span></span><span><span>We take ownership and work together to deliver excellence.  </span></span><span> <br></span><span><span>Constructive Bio is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.    </span></span><span> </span></li>\n</ul>\n<p><span><span>Please note that we work in a dog-friendly office </span></span><span> </span></p>",
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