Software Engineer Lead

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California. Summary: We are seeking an experienced Software Engineer Lead to provide technical leadership for the development, enhancement, and support of software applications in a regulated clinical laboratory environment. This role will lead the design and delivery of software solutions, guide engineering best practices, mentor team members, and collaborate closely with business and technical stakeholders to deliver secure, reliable, and compliant applications. The ideal candidate combines strong software engineering expertise, hands-on development experience, operational awareness, and experience working in regulated healthcare environments. This individual will serve as a technical leader for the team, driving software quality, architectural consistency, and successful project execution while supporting critical laboratory and business operations. Onsite: Monday, Tuesday, and Thursday Responsibilities: Lead the design, development, testing, deployment, and maintenance of software applications supporting laboratory and business operations. Be a hands-on implementation lead for software projects using the latest technologies for software development and integrations, and also manage a small team of engineers for this. Participate actively in software design, code reviews, troubleshooting, and implementation activities. Be a champion of software best practices in partnership with QA by conducting risk analysis, identifying test data, and improving CI/CD within Informatics and stakeholder teams aimed at high quality deliverables. Promote engineering best practices for software quality, security, performance, maintainability, and reliability. Support Agile development processes including sprint planning, backlog refinement, estimation, and release planning. Ensure software solutions comply with applicable regulatory requirements including HIPAA, CLIA, CAP, FDA (as applicable), and internal quality standards. Support validation, documentation, audit readiness, and compliance activities. Requirements: Bachelor's degree in Computer Science, Information Technology, Engineering, or related field. 6+ years of software development experience. 2+ years serving as a technical lead, senior engineer, or equivalent leadership role. Demonstrated expertise across the full software development stack, including Python, Java, JavaScript, database design and management, DevOps practices, CI/CD automation, and modern software engineering principles. Experience working in a regulated healthcare, diagnostics, laboratory, or life sciences environment. Experience supporting production applications and resolving complex technical issues. Experience working with distributed or offshore development teams. Experience with enterprise application and automation system integrations. Strong understanding of Agile methodologies including Scrum and Kanban. Experience with cloud platforms such as AWS, Azure, or GCP. Strong experience with APIs, microservices, and modern application architectures. Excellent problem-solving, analytical, and communication skills. The hiring range for this position is $190,000 to $220,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered. Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you. Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @ personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community. Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) #LI-KK1 #LI-Hybrid

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