Senior Director, Screening Platform Technology

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: We are seeking an experienced Senior Director of Screening Platform Technology to lead a multidisciplinary team responsible for the design, execution, and evolution of Revolution Medicines’ screening platforms. This role will oversee assay operations, new process implementation, and screening analytics and controls, and will partner closely with software engineers, automation engineers, and a cross-functional screening strategy taskforce. The successful candidate will bring strong people leadership, deep experience in high-throughput screening platforms, and direct technical expertise in screening analytics and data-driven experimental design. Lead and develop a team of approximately 7–10 scientists and technical staff across assay operations, new process implementation, and screening analytics and controls. Provide strategic and technical leadership for HTS platform development in close partnership with software engineering, automation engineering, and cross-functional stakeholders. Own the end-to-end screening platform, ensuring robust integration of robotics, instrumentation, software, and data pipelines. Drive adoption of advanced screening analytics, including quality control frameworks, longitudinal analysis across campaigns, and AI-enabled or data-driven experimental design. Serve as a technical thought partner to discovery teams, translating scientific questions into effective screening strategies and interpretable data outputs. Establish best practices for screening data integrity, reproducibility, and insight generation. Serve as the primary point of contact for cross-functional partners, ensuring timely and accurate delivery of materials. Work closely with the Director of Sample Management to communicate capacity, risks, and resource needs. Support onboarding and ramp-up of new staff and technologies within the laboratory. Required Skills, Experience and Education: Bachelor’s degree in Chemistry or a related field with a minimum of 12 years of relevant experience, Master’s degree with at least 10 years of relevant experience, or Ph.D. with a minimum of 8 years of relevant experience; a combination of direct and related industry experience is preferred Demonstrated success leading and developing large multidisciplinary teams, including experience managing managers, sub-team leads, and senior scientific contributors across matrixed organizations. Extensive experience designing, implementing, and operating HTS platforms in collaboration with automation and software engineering teams. Direct, hands-on expertise in screening data analytics, including statistical analysis, controls, longitudinal data analysis, and experimental design. Experience applying or evaluating machine learning or AI-driven approaches to screening strategy and data interpretation. Strong enterprise- and systems-level thinking with the ability to balance innovation, organizational scale, and pragmatic delivery of results. Excellent written and verbal communication skills. Preferred Skills: Experience shaping or modernizing screening platforms in a growing discovery organization. Familiarity with scalable data and analytics frameworks for screening and discovery. Oncology or small-molecule drug discovery experience. #LI-Hybrid #LI-LN1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy . For additional information, please contact [email protected] . Base Pay Salary Range $244,000 — $305,000 USD We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to [email protected] so we can share these impersonations with our IT team for tracking and awareness.

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