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Principal Scientist – Antibody Discovery/Protein Design

68015e6d Be52 4be3 A41e Cd0f60737bd5 19000101 000001 · Branford, CT, US, Branford, CT · On Site · Active · ADP Workforce Now Recruiting

Job facts

FieldValue
Company68015e6d Be52 4be3 A41e Cd0f60737bd5 19000101 000001
TitlePrincipal Scientist – Antibody Discovery/Protein Design
Normalized title-
Department / team-
LocationBranford, CT, United States
Work modelOn Site
Employment typeFull Time
Salary-
Statusactive
ATS providerADP Workforce Now Recruiting
Posted / first seen2026-05-08 / 2026-05-31
Changed / last seen2026-06-06 / 2026-06-06

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Linked records

Company68015e6d Be52 4be3 A41e Cd0f60737bd5 19000101 000001
Sourcea2af94a9-6f20-4ae7-aa52-c7ec7b03bf44
ATS providerADP Workforce Now Recruiting

Description

Join a company where your science will directly shape the future of cancer immunotherapy Who We Are EvolveImmune Therapeutics is a privately-held, next-generation immuno-oncology company pioneering a new class of T cell engager therapies to transform cancer patient outcomes compared to current immunotherapies. Our first-in-category biotherapeutic EVOLVE platform utilizes integrated T cell costimulation to directly target tumor cells to deliver durable anti-tumor adaptive immune responses. Our lead asset, EVOLVE104, entered clinical trials in late 2025. Additional collaboration pipeline programs (with Abbvie) and wholly owned programs are progressing toward candidate nomination. EvolveImmune’s team consists of ~50 FTEs in R&D, business development, people & culture, finance and operations. Our newly expanded, state-of-the-art 20,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor is convenient to the amenities of the Connecticut shoreline, the city of New Haven and easy travel options throughout the Boston/New York City corridor. We're hiring a Principal Scientist to join our Biotherapeutics group focused on designing and advancing first-in-class immune-engaging biologics. If you’re a protein engineer with expertise in computational protein design with experimental experience in protein discovery and optimization through antibody display technologie s with an interest in advancing drug candidate toward first-in-patient evaluation, this role offers real opportunity, purpose, and scientific challenge. What You’ll Work on Design and optimize novel antibody-based multispecifics targeting domains using AI/ML-model-based de novo sequence discovery Lead antibody engineering and antibody display-based screening from idea to experimental execution including screening, hit prioritization, and initial characterization. Optimize developability in lead optimization through computational and biophysical insights Expand company computational protein design tools and capabilities Collaborate across functional teams to support candidate selection and preclinical development Present findings in a clear, compelling way to multidisciplinary teams Mentor junior scientists and help shape our growing discovery efforts _______________________________________ What You Bring PhD in biochemistry, computational biology, or structural biology, and postdoctoral fellowship in a related field with 5+ years of antibody and biotherapeutic engineering industry experience Foundation in protein design and molecular modeling using AI/ML Yeast or alternative antibody display technologies experience from design through screening Expertise in bispecific or multispecific protein design, expression, purification, and biophysical characterization Strong communication, data interpretation, and cross-functional collaboration skills ________________________________________ What You’ll Gain A hands-on, high-impact role shaping the design of next-generation immunotherapies Opportunity to see your work move rapidly from concept to clinic A visible position within the Biotherapeutics team, contributing directly to platform and pipeline innovation A chance to collaborate across disciplines and influence key program decisions Professional growth through exposure to diverse scientific challenges and cross-functional projects Optional mentorship opportunities and the ability to help shape a growing discovery organization A mission-driven, fast-paced biotech environment that values bold thinking and scientific excellence A supportive, open culture built on collaboration, trust, and shared purpose ________________________________________ Why You’ll Love Working Here • Direct impact: Your science will influence platform design and shape next-generation clinical programs. • Cutting-edge science: Help pioneer new approaches to T cell redirection in solid tumors. • Personal growth: Gain exposure to every stage of early discovery in a collaborative biotech setting. • Collaborative culture : Join a supportive, curious, and driven team aligned around scientific innovation and patient outcomes. • Top-tier facilities : Work in a brand-new, purpose-built lab and office space near New Haven, CT. • Mission with meaning : Join a company working to give more patients real hope in the fight against cancer. ________________________________________ Additional Info • This is a full-time, onsite position based in Branford, CT • EvolveImmune requires COVID-19 vaccination; medical and religious accommodations will be considered • We offer competitive salary, benefits, equity, and paid time off • We are an equal opportunity employer and value diverse perspectives in all aspects of our work • Learn more about our science and our team at www.evolveimmune.com ________________________________________ Search Keywords Antibody Engineering | Yeast/phage Display Technologies | AI/ML Protein Design tools | Bispecific Antibodies | Protein Engineering | Biotherapeutics | Biologics Development | T Cell Engager | Branford Biotech Jobs | Scientist Antibody Discovery | Immunotherapy Careers | Cancer Biotech | Molecular Biology | Biotech Scientist CT | New Haven Biotech | Oncology Drug Discovery | EvolveImmune Careers

Full job record

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Last Seen At2026-06-06 12:20:55Z
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Additional collaboration pipeline programs (with Abbvie) and wholly owned programs are progressing toward candidate nomination. EvolveImmune&rsquo;s team consists of ~50 FTEs in R&amp;D, business development, people &amp; culture, finance and operations. Our newly expanded, state-of-the-art 20,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor is convenient to the amenities of the Connecticut shoreline, the city of New Haven and easy travel options throughout the Boston/New York City corridor.</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">We&#39;re hiring a <strong>Principal Scientist</strong> to join our <strong>Biotherapeutics group</strong> focused on designing and advancing first-in-class immune-engaging biologics. If you&rsquo;re a protein engineer with <strong>expertise in computational protein design with experimental experience in protein discovery and optimization through antibody display technologie</strong>s with an interest in advancing drug candidate toward first-in-patient evaluation, this role offers real opportunity, purpose, and scientific challenge.</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\"><strong>What You&rsquo;ll Work on</strong></span></p><div style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Calibri\",sans-serif;' data-pasted=\"true\"><ul style=\"margin-bottom:0in;list-style-type: disc;margin-left: 0in;\"><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">Design and optimize novel antibody-based multispecifics targeting domains using AI/ML-model-based <em>de novo</em> sequence discovery</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\"><span style=\"color: black;\">Lead antibody engineering and antibody display-based screening from idea to experimental execution including screening, hit prioritization, and initial characterization.</span></li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\"><span style=\"color: black;\">Optimize developability in lead optimization through computational and biophysical insights&nbsp;</span></li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\"><span style=\"color: black;\">Expand company computational protein design tools and capabilities&nbsp;</span></li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">Collaborate across functional teams to support candidate selection and preclinical development</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">Present findings in a clear, compelling way to multidisciplinary teams</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">Mentor junior scientists and help shape our growing discovery efforts</li></ul></div><div style=\"margin-left:0in;\"><p><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\"><br></span></p></div><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">_______________________________________</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\"><strong>What You Bring&nbsp;</strong></span></p><div style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Calibri\",sans-serif;' data-pasted=\"true\"><ul style=\"margin-bottom:0in;list-style-type: disc;margin-left: 0in;\"><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">PhD in biochemistry, computational biology, or structural biology, and postdoctoral fellowship in a related field with 5+ years of antibody and biotherapeutic engineering industry experience</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">Foundation in protein design and molecular modeling using AI/ML</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">Yeast or alternative antibody display technologies experience from design through screening</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">Expertise in bispecific or multispecific protein design, expression, purification, and biophysical characterization</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">Strong communication, data interpretation, and cross-functional collaboration skills</li></ul></div><div style=\"margin-left:0in;\"><p><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\"><br></span></p></div><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">________________________________________</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\"><strong>What You&rsquo;ll Gain&nbsp;</strong></span></p><div style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Calibri\",sans-serif;' data-pasted=\"true\"><ul style=\"margin-bottom:0in;list-style-type: disc;margin-left: 0in;\"><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">A hands-on, high-impact role shaping the design of next-generation immunotherapies</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">Opportunity to see your work move rapidly from concept to clinic</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">A visible position within the Biotherapeutics team, contributing directly to platform and pipeline innovation</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">A chance to collaborate across disciplines and influence key program decisions</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">Professional growth through exposure to diverse scientific challenges and cross-functional projects</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">Optional mentorship opportunities and the ability to help shape a growing discovery organization</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">A mission-driven, fast-paced biotech environment that values bold thinking and scientific excellence</li><li style=\"margin: 0in 0in 8pt; line-height: 115%; font-size: 14px; font-family: tahoma, sans-serif;\">A supportive, open culture built on collaboration, trust, and shared purpose</li></ul></div><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">________________________________________</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\"><strong>Why You&rsquo;ll Love Working Here</strong></span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">&bull; <strong>&nbsp;Direct impact:</strong> Your science will influence platform design and shape next-generation clinical programs.</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">&bull; <strong>Cutting-edge science:</strong> Help pioneer new approaches to T cell redirection in solid tumors.</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">&bull; <strong>&nbsp;Personal growth:</strong> Gain exposure to every stage of early discovery in a collaborative biotech setting.</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">&bull; <strong>Collaborative culture</strong>: Join a supportive, curious, and driven team aligned around scientific innovation and patient outcomes.</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">&bull; <strong>&nbsp;Top-tier facilities</strong>: Work in a brand-new, purpose-built lab and office space near New Haven, CT.</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">&bull; <strong>Mission with meaning</strong>: Join a company working to give more patients real hope in the fight against cancer.</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">________________________________________</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\"><strong>Additional Info&nbsp;</strong></span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">&bull; This is a full-time, onsite position based in Branford, CT</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">&bull; EvolveImmune requires COVID-19 vaccination; medical and religious accommodations will be considered</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">&bull; We offer competitive salary, benefits, equity, and paid time off</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">&bull; We are an equal opportunity employer and value diverse perspectives in all aspects of our work</span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">&bull; Learn more about our science and our team at <a href=\"https://www.evolveimmune.com/\" target=\"_blank\" style=\"font-size: 14px;\">www.evolveimmune.com</a></span></p><p style=\"margin-left:0in;\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">________________________________________</span></p><p style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Calibri\",sans-serif;' data-pasted=\"true\"><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\"><strong>Search Keywords</strong></span></p><p style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Calibri\",sans-serif;'><span style=\"font-family: tahoma, sans-serif; font-size: 14px;\">Antibody Engineering | Yeast/phage Display Technologies | AI/ML Protein Design tools | Bispecific Antibodies | Protein Engineering | Biotherapeutics | Biologics Development | T Cell Engager | Branford Biotech Jobs | Scientist Antibody Discovery | Immunotherapy Careers | Cancer Biotech | Molecular Biology | Biotech Scientist CT | New Haven Biotech | Oncology Drug Discovery | EvolveImmune Careers</span></p></div></div></div></div>\n",
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    "postingInstructions": [],
    "additionalProperties": {},
    "requisitionLocations": [
      {
        "address": {
          "cityName": "Branford",
          "postalCode": "06405",
          "countrySubdivisionLevel1": {
            "codeValue": "CT"
          }
        },
        "nameCode": {
          "shortName": " Branford, CT, US"
        },
        "aliasNames": []
      }
    ],
    "screeningRequirements": [],
    "sponsoredVisaTypeCodes": []
  },
  "detail_meta": {
    "url": "https://workforcenow.adp.com/mascsr/default/careercenter/public/events/staffing/v1/job-requisitions/553199?cid=68015e6d-be52-4be3-a41e-cd0f60737bd5&ccId=19000101_000001&lang=en_US&locale=en_US",
    "http_status": 200,
    "content_type": "application/json;charset=UTF-8",
    "response_bytes": 16980
  },
  "detail_errors": []
}
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GET https://api.bluedoor.sh/job-postings/v1/jobs/bde5f837ec9085a589f354096d1cde39a4533ab4?include=descriptionJSON
GET https://api.bluedoor.sh/job-postings/v1/orgs/d8001f8f-9820-4106-a772-5a9b37fb8104JSON
GET https://api.bluedoor.sh/job-postings/v1/sources/a2af94a9-6f20-4ae7-aa52-c7ec7b03bf44JSON
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