Director, Target Biology

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Targets and Mechanisms group within Discovery Biology leverages expertise in cancer biology and deep mechanistic understanding of cancer-relevant pathways to identify and characterize high-priority oncology targets for our tri-complex inhibitor (TCI) platform. We are looking for an experienced drug hunter to lead the Target Biology team, provide hands-on scientific and people leadership, and work cross-functionally to identify and rapidly assess promising new targets, determine hit identification strategy, and advance screening hits through the early stages of hit-to-lead discovery. The ideal candidate will be a strategic thinker and an accomplished scientist with experience identifying and vetting targets for oncology programs, familiarity with different targeting modalities, including molecular glues, and hands-on hit to lead experience. In this role you will: Lead a team of scientists focused on target identification, prioritization, and biological validation. Work cross-functionally with partners in Medicinal Chemistry, Structural Biology, Discovery Biology, Translational Research, and Cancer Immunology to prioritize oncology targets, implement hit discovery plans, and drive progression from hit identification through lead generation. Collaborate with the Translational Research function to apply learnings from clinical and preclinical studies to inform new target identification and prioritization. Spearhead innovative approaches and technologies for target discovery and hit identification, specifically in the context of hard-to-drug oncology targets. Provide scientific leadership to the team, including technical guidance, coaching, and mentoring. Foster a culture of curiosity, scientific rigor, and excellence, driven by RevMed’s core values and commitment to improving patients’ lives. Implement data-driven decision-making processes to prioritize targets and allocate resources effectively. Required Skills, Experience and Education: We are looking for a driven team leader and an excellent team player to guide the Target Biology team and support overall Discovery Biology efforts. PhD in chemical biology, cell-biology, biochemistry, or a related scientific discipline. Minimum of 10 years of industry experience, ideally in early-stage drug discovery. Experience as a team leader in an industry setting with demonstrated ability to build strong cross-functional relationships and effectively drive early discovery programs. Proven problem solver with strong scientific background and expertise in experimental design and data interpretation. Excellent communication and decision-making skills. Preferred Skills: Knowledge of molecular glue discovery, cellular models, phenotypic screening, and target identification by chemical labeling. Familiarity with multi-omics data, genetic screens (e.g., synthetic lethality) and their application in early discovery. Experience applying advanced analytical techniques (e.g. AI and ML) to generate hypotheses from large, multidimensional data sets. Project team leadership experience in early-stage discovery programs. Experience working with different modalities, such as small molecules, biologics, and molecular glues. #LI-Hybrid #LI-LN1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy . For additional information, please contact [email protected] . Base Pay Salary Range $211,000 — $264,000 USD We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to [email protected] so we can share these impersonations with our IT team for tracking and awareness.

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