Senior Manager, Supply Planning

Company Overview: Beam Therapeutics is a biotechnology company committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform with integrated gene editing, delivery and internal manufacturing capabilities. Beam’s suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases. Position Overview: Beam is seeking a highly motivated individual to join our Supply Chain team. The Supply Planning & Network leader will be responsible managing the global supply network performance by conducting risk-based inventory reviews and developing strategic options to address demand uncertainties and enhance network capabilities. He/she will be accountable to ensure uninterrupted supply of clinical and future commercial products via Beam’s S&OP process. This role will report to the Sr. Director of Global Supply Chain Planning and partner with TechOps, Clinical Ops, Commercial Patient Ops, Quality, Finance, and CMC teams to lead short-term integrated production planning and long-range strategic supply chain planning of Beam’s product portfolio. The role will be responsible for leading a global inventory management program to ensure critical material availability at Beam NC & CDMO mfg sites. The role will be integral to enhancing site planning and scheduling capabilities at Beam’s mfg site in Durham, NC and partnering with SAP business lead on further advancing technology capabilities. The ideal candidate will have a demonstrated track record of leading in a dynamic environment. They will also possess the ability to successfully interface with multidisciplinary teams and build strong cross functional relationships. Responsibilities: Production & Capacity Planning: Develop and maintain a rolling 12–24-month master production schedule (MPS) aligned with demand forecasts and manufacturing constraints. External Network Collaboration: Lead planning and partner with key stakeholders to ensure supply continuity across the Contract Manufacturing Organizations (CMOs) and 3PLs. Sales & Operations Planning (S&OP): Drive the monthly S&OP cycle, including rough-cut capacity planning and scenario analysis. Partner cross-functionally to refine demand forecasts and execute supply network analysis to support both tactical and strategic goals. Inventory Optimization: Ensures appropriate inventory levels to minimize excess while preventing stockouts, specifically managing shelf-life/expiry for temperature-sensitive products like Critical Materials (pDNA, mRNA, gRNA, mAb, lipids), Drug Substance, and Bulk/Finished Drug Product. Clinical/Launch Readiness: Orchestrate supply for clinical trials or support new product introductions (NPI) and commercial launches. Risk Management: Proactively identify supply disruptions and develop mitigation strategies or business continuity plans. Process Improvement: Drive Global Supply Chain excellence through project management, process enhancement, and the deployment of digital tools that streamline business execution and strategic decision-making. Metrics: Leverage data-driven KPIs to track performance, ensuring accountability and optimizing the balance between operational efficiency and financial health. Systems: Optimize supply and inventory planning accuracy through utilization of SAP, driving improved stock maintenance and network visibility. Spearhead the design and execution of SAP enhancements, including Integrated Business Planning (IBP) and Jurisdictional Control (JC), to streamline end-to-end supply chain functions. Other duties as assigned. Qualifications: BS/BA degree in Business, Science, Engineering or related field with 8-10+ years of experience in global supply chain from pharma, biotech or cell & gene therapy companies. Master's degree or MBA preferred. Prior drug development, manufacturing, and clinical operations experience is a plus. Final title/scope of role will be commensurate with experience. Passion for patients, collaborative and effective leader. Knowledge of practical implications of Sarbanes-Oxley controls. Knowledge of continuous improvement methodologies and tools. Strong organizational and facilitation skills, with high degree of customer focus. Expertise and track record in manufacturing and supply chain execution and oversight. Extensive experience in supply chain planning, SAP ERP system, capacity modeling, supply network strategy and optimization. Expertise and have a proven track record in supply chain risk management. Solid knowledge of regulatory requirements, regulatory guidance, including pharmaceutical GMPs and ICH guidance. Current on Biopharma supply chain, manufacturing technologies, supplier network, CMO network, performance and capacity. Possesses understanding and application of principles, concepts, practices, and standards for DS and DP manufacturing in the biopharma industry. Strong communication, negotiation, and interpersonal skills. Strong analytical skills and ability to clearly communicate at tactical and strategic level with team and Sr Management. Ability to work in a dynamic and challenging environment. Some travel may be required. Must be able to work onsite, not a remote role. The salary range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, education, scope of job, internal comparisons, and market data. Beam Pay Range $155,000 — $190,000 USD

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