Scientist I/II, Organic Chemistry

Your Impact at LILA The Scientist I/II, Organic Chemistry will develop, execute, and optimize modern chemical transformations that support Discovery Chemistry efforts across Lila’s platform, with a focus on the rapid synthesis of small molecules and structurally diverse chemical matter. This role is intended for an experimental organic chemist who combines strong foundations in synthetic chemistry with hands-on experience in high-throughput experimentation (HTE), reaction workup, and analytical characterization . Working closely with Discovery Chemistry, analytical chemistry, automation, screening, and AI/computational teams, this scientist will help build and apply efficient chemistry workflows that accelerate molecular design–make–test–analyze cycles. The Scientist II will contribute to reaction development, analog generation, and route execution using modern organic chemistry approaches that are compatible with scalable, data-rich, and increasingly automated discovery environments. This role is ideal for a chemist excited by solving synthetic problems at the interface of reaction innovation, high-throughput experimentation, process efficiency, and analytical insight , and who is motivated to help shape next-generation discovery workflows beyond traditional bench chemistry. What You'll Be Building Design, execute, and optimize chemical transformations relevant to Discovery Chemistry programs, with emphasis on the rapid synthesis of small molecules and analog series. Apply modern synthetic organic chemistry to enable efficient exploration of structurally diverse and medicinally relevant chemical space. Plan and perform multi-step synthesis, reaction optimization, workup, purification, and compound characterization in support of molecular discovery campaigns. Design and execute HTE workflows for reaction screening, condition optimization, reagent evaluation, and rapid assessment of transformation scope. Develop robust approaches for reaction setup, reaction workup, sample preparation, and analytical readout to support fast and information-rich experimentation. Use analytical tools such as chromatography, NMR , and related methods to assess reaction performance, characterize products, and guide synthetic decisions. Contribute to the development of practical and scalable chemistry workflows that integrate reaction discovery, reaction optimization, and downstream compound generation. Partner closely with Discovery Chemistry scientists to translate molecular design concepts into executable synthetic strategies and experimentally tractable reaction plans. Collaborate with analytical chemistry and automation teams to build workflows that connect reaction execution with streamlined workup, purification, and data generation. Support the adaptation of synthetic workflows to parallel, automated, or robotics-enabled platforms where appropriate. Interpret reaction and analytical data rigorously, identify bottlenecks, and propose solutions to improve efficiency, robustness, and reproducibility. What You’ll Need to Succeed PhD in Organic Chemistry, Medicinal Chemistry, or a closely related discipline with relevant postdoctoral and/or industry experience. Strong expertise in synthetic organic chemistry , including design and execution of multi-step synthesis and development of chemical transformations relevant to small molecule discovery. Hands-on experience with HTE for reaction screening, optimization, or scope evaluation. Experience with reaction workup, sample preparation, purification, and analytical characterization in fast-paced synthetic workflows. Strong working knowledge of analytical methods commonly used to support organic synthesis. Demonstrated ability to troubleshoot challenging reactions and independently solve synthetic and experimental problems. Strong understanding of how reaction design, execution, workup, and analysis fit together in efficient discovery workflows. Ability to work effectively in interdisciplinary environments spanning chemistry, analytics, automation, and computational sciences. Strong organizational, documentation, and communication skills, with commitment to scientific rigor and reproducibility. Bonus Points For Experience supporting Discovery Chemistry or medicinal chemistry programs in biotech, pharma, or advanced research environments. Familiarity with modern reaction classes relevant to small molecule discovery, including coupling chemistry, heterocycle synthesis, late-stage functionalization, and rapid analog generation. Experience with parallel synthesis or robotics-enabled chemistry workflows. Exposure to data-rich, AI-enabled, or platform-based R&D environments. Collaborative mindset and enthusiasm for building modern chemistry capabilities that go beyond traditional bench-scale synthesis. Compensation We offer competitive base compensation with bonus potential and generous early-stage equity. Your final offer will reflect your background, expertise, and expected impact. U.S. Benefits. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. International Benefits. Full-time employees outside the U.S. receive a comprehensive benefits program tailored to their region. USD salary ranges apply only to U.S.-based positions; international salaries are set to local market. Expected Base Salary Range $108,000 — $170,000 USD About LILA Lila Sciences is building Scientific Superintelligence™ to solve humankind's greatest challenges. We believe science is the most inspiring frontier for AI. Rather than hard-coding expert knowledge into tools, LILA builds systems that can learn for themselves. LILA combines advanced AI models with proprietary AI Science Factory™ instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy. Learn more at www.lila.ai. Guided by our core values of truth, trust, curiosity, grit, and velocity, we move with startup speed while tackling problems of historic importance. If this sounds like an environment you'd love to work in, even if you don't meet every qualification listed above, we encourage you to apply. We’re All In Lila Sciences is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Information you provide during your application process will be handled in accordance with our Candidate Privacy Policy . A Note to Agencies Lila Sciences does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Lila Sciences or its employees is strictly prohibited unless contacted directly by Lila Science’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Lila Sciences, and Lila Sciences will not owe any referral or other fees with respect thereto.

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