Downstream Processing (DSP) Scientist

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    "description": "<p><br><span style=\"font-weight: bold\"><span><span>Who we are:    </span></span></span><span> </span></p>\n<p><br><span> </span></p>\n<p><span><span>Life, Reimagined     </span></span><span> <br></span><span><br></span><span> </span></p>\n<p><span><span>Constructive Bio is a VC-backed biotechnology startup based in Whittlesford, Cambridge. Our unique technology turns living cells into </span><span>biofactories</span><span>, creating sustainable new materials and therapeutics. With full control of the genetic sequence and code, we are exploring chemical space previously unreached by natural biology.   </span></span><span> <br></span><span><br></span><span> </span></p>\n<p><span><span>Constructive Bio is a spinout from Professor Jason Chin's laboratory at the MRC Laboratory of Molecular Biology in Cambridge. Learn more about the Chin lab achievements here: </span></span><a href=\"https://www2.mrc-lmb.cam.ac.uk/ccsb/jason-chin/\" target=\"_blank\" rel=\"noopener noreferrer\"><span><span>https://www2.mrc-lmb.cam.ac.uk/ccsb/jason-chin/</span></span></a><span><br></span><span> <br></span><span><br></span><span> </span></p>\n<p><span><span>We secured $58 million Series A fundraising. Read more here: </span></span><a href=\"https://www.constructive.bio/blog/news/constructive-bio-secures-58-million-in-series-a-financing\" target=\"_blank\" rel=\"noopener noreferrer\"><span><span>https://www.constructive.bio/blog/news/constructive-bio-secures-58-million-in-series-a-financing</span></span></a><span><br></span><span> </span></p>\n<p><br><span> </span></p>\n<p><span style=\"font-weight: bold\"><span><span>What </span><span>we’re</span><span> looking for:  </span></span></span><span> </span></p>\n<p><span><span>We are looking for a driven </span></span><span><span>Downstream processing (DSP)</span><span> Scientist</span></span><span><span> to join our dynamic, collaborative group. This role will help us strengthen our route to commerciali</span><span>s</span><span>ation, enabling the scalable production of peptides and proteins with non-standard amino acids from our proprietary recoded strain of </span></span><span><span>E. coli</span></span><span><span>: </span></span><span><span>Syn61</span></span><span><span>. This platform has broad potential applications in new biologics therapies and beyond. Besides technical process development, the role requires ensuring communication between commercial and scientific teams. This position plays a significant part in our operations and the broader bioprocessing field, with great opportunities for role advancement.</span></span><span> </span></p>\n<p><span> </span></p>\n<p><span><span>The ideal candidate will have experience working with</span><span> and processing material from</span><span> bacterial cultures at a range of scales, a drive to progress innovative technologies, and an eagerness to learn.</span></span><span> </span></p>\n<p><span> </span></p>\n<p><span style=\"font-weight: bold\"><span><span>Responsibilities:</span></span></span><span> </span></p>\n<ul>\n<li><span><span>Develop, optimi</span><span>s</span><span>e, and scale-up </span><span>Downstream </span><span>microbial bioprocesses for a range of recombinant </span><span>therapeutic </span><span>proteins</span><span> and</span><span> peptides</span><span>. </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Utili</span><span>s</span><span>e various protein </span><span>analytical</span><span> techniques to assess quality</span><span> &amp; stability</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Plan and conduct experiments for process optimi</span><span>s</span><span>ation</span><span>, </span><span>characteri</span><span>s</span><span>ation</span><span> and quantification.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Support technology transfer to manufacturing and </span><span>assist</span><span> with process validation activities.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Contribute</span><span> to the </span><span>Technoeconomic assessment </span><span>of Bioprocesses</span><span>.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Stay current with the latest bioprocessing techniques and technologies.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Ensure work is performed </span><span>in accordance with</span><span> safety and quality system procedures.</span></span><span> </span></li>\n</ul>\n<p><span> </span></p>\n<p><span style=\"font-weight: bold\"><span><span>Requirements:</span></span></span><span> </span></p>\n<ul>\n<li><span><span>Minimum of a </span><span>Bachelor’s</span><span> degree in Biochemical Engineering, Biochemistry, Biotechnology, or related field.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Demonstrated project delivery in a relevant industrial setting. Experience in a GMP environment is a plus.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Experience</span><span> </span><span>developing </span><span>scalable </span><span>do</span><span>wn</span><span>stream </span><span>processes </span><span>for </span><span>high cell density microbial </span><span>broth </span><span>via </span><span>e.g</span><span> cell </span><span>disruption</span><span>, centrifugation</span><span>, filtration.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Experience with protein purification techniques, including chromatography (HPLC, FPLC, etc.) and tangential flow filtration (TFF).</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Understanding of protein biochemistry and structural biology.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Familiarity with protein analytical techniques such as SDS-PAGE, Western Blot, etc.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Strong problem-solving skills, good oral and written communication skills, and the ability to work effectively in cross-functional teams.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Ability to effectively manage multiple projects and prioritize tasks.</span></span><span> </span></li>\n</ul>\n<p><span> </span></p>\n<p><span style=\"font-weight: bold\"><span><span>Desirable Skills:</span></span></span><span> </span></p>\n<ul>\n<li><span><span>Familiarity with high cell density fermentation for </span></span><span><span>E. coli</span></span><span><span> in bench-top bioreactors.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Experience with </span><span>HPLC/LC-MS character</span><span>isation of Peptides</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Experience with design of experiment (DOE) </span><span>methodology</span><span>.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Familiarity with Quality by Design (</span><span>QbD</span><span>) principles.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Familiarity with DOE and other statistical techniques.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Previous</span><span> experience with tech transfer and scale-up processes.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Knowledge of regulatory requirements associated with biopharmaceutical process development.</span></span><span> </span></li>\n</ul>\n<p><span> </span></p>\n<p><span style=\"font-weight: bold\"><span><span>What’s</span><span> in it for you? Why work at Constructive Bio?    </span></span></span><span> <br></span><span><br></span><span> </span></p>\n<p><span><span>We are a small but rapidly growing team, with a vision to become the programmable biomolecules company and push the boundaries of </span><span>what’s</span><span> possible between biology and chemistry. As an early joiner, you will have a unique opportunity to help shape our trajectory and make real impact from day one.    </span></span><span> </span></p>\n<p><br><span> <br></span><span style=\"font-weight: bold\"><span><span>We offer:   </span></span></span><span> </span></p>\n<p><br><span> </span></p>\n<ul>\n<li><span><span>Newly fitted dedicated site in Whittlesford near Cambridge – on-site parking and regular trains to Cambridge, </span><span>London</span><span> and Norwich   </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Competitive salary   </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Employee share option plan   </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>25 days holiday plus bank holidays   </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Private health insurance   </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Pension plan (matching up to 8%)   </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Collaborative and pioneering environment, at the leading edge of synthetic genomics and engineered translation   </span></span><span> </span></li>\n</ul>\n<p><span><br></span><span> <br></span><span><br></span><span> </span></p>\n<p><span><span>We want to build a team with trust and respect for each other and create a culture of collaboration, openness, curiosity, and scientific excellence.     </span></span><span> </span></p>\n<p><span><br></span><span> <br></span><span><span>We are built on three principles:    </span></span><span> <br></span><br><span> </span></p>\n<ul>\n<li><span style=\"font-weight: bold\"><span><span>We imagine: </span></span></span><span><span>We think big and plan our own path for success.     </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span style=\"font-weight: bold\"><span><span>We pioneer: </span></span></span><span><span>We </span><span>take action</span><span> and grow together as one to break moulds.    </span></span><span> </span></li>\n</ul>\n<ul>\n<li><span style=\"font-weight: bold\"><span><span>We deliver: </span></span></span><span><span>We take ownership and work together to deliver excellence.    </span></span><span> </span></li>\n</ul>\n<p><span><br></span><span> <br></span><span><span>Constructive Bio is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.    </span></span><span> </span></p>\n<p><span><span>Please note that we work in a dog-friendly office </span></span><span> </span></p>\n<p><br><span> </span></p>\n<p><span> </span></p>",
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