Scientist, Drug Discovery

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    "html_title": "GondolaBio Service Co, Inc. - Scientist, Drug Discovery",
    "description_html": "<p><strong>Job Type:&nbsp;</strong>Full-time, On-site&nbsp;</p><p><br></p><p><strong>Scientist,&nbsp;Drug Discovery</strong></p><p>Palo Alto, CA</p><p><br></p><p><strong>About&nbsp;GondolaBio</strong>&nbsp;</p><p>GondolaBio&nbsp;is a clinical-stage biopharmaceutical company focused on developing breakthrough therapeutics for genetic diseases.&nbsp;GondolaBio&nbsp;is an independent sister company to&nbsp;BridgeBio, originally carved out in 2024 after securing $300M in private financing from external investors.&nbsp;GondolaBio&nbsp;aims to&nbsp;leverage&nbsp;cutting-edge&nbsp;biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases. Located on the Stanford Life Sciences campus,&nbsp;GondolaBio&nbsp;fosters a unique hybrid environment where top scientists from around the world collaborate with senior leadership and advisors, blending industry&nbsp;expertise&nbsp;with academic innovation.&nbsp;</p><p><br></p><p><strong>Who You Are</strong>&nbsp;</p><ul><li>A deeply motivated scientist with&nbsp;a strong sense&nbsp;of urgency, dedicated to designing creative, high-impact&nbsp;experiments to solve complex problems in drug discovery.&nbsp;</li><li>Detail-oriented and execution-focused, with&nbsp;a strong foundation&nbsp;in&nbsp;molecular&nbsp;and cellular&nbsp;biology&nbsp;techniques,&nbsp;and&nbsp;a <strong>compelling publication record </strong>demonstrating&nbsp;scientific rigor and independence.</li><li><strong>Productivity-driven</strong>: you naturally like&nbsp;multi-tasking&nbsp;and getting more done.&nbsp;</li><li>Comfortable partnering tightly with <strong>chemistry/computational biology/structural biology/DMPK/tox </strong>to interpret SAR biologically, and drive hit-to-lead decisions.</li><li>A crisp communicator and pragmatic operator who can lead internally and through <strong>CROs/academic collaborators </strong>with&nbsp;high standards.&nbsp;</li><li>You approach experimental failures with a growth mindset, and embrace changing directions and priorities&nbsp;based on project and company needs&nbsp;&nbsp;</li></ul><p><strong>Key Responsibilities</strong>&nbsp;</p><ul><li>Engineering&nbsp;and&nbsp;optimizing&nbsp;transgenic&nbsp;<strong>mammalian&nbsp;</strong><em><strong>in vitro&nbsp;</strong></em><strong>cell models</strong>&nbsp;for therapeutic screening and&nbsp;characterization.&nbsp;</li><li><strong>Quantitative assay development</strong>&nbsp;using flow cytometry, microscopy,&nbsp;transcriptomics,&nbsp;proteomics&nbsp;and microplate readers.&nbsp;This is a&nbsp;<strong>hybrid&nbsp;experimental and computational role</strong>. You will generate high-throughput data&nbsp;and then&nbsp;set&nbsp;up computational workflows for&nbsp;analyzing these data.&nbsp;</li><li>Stay&nbsp;super-organized with&nbsp;experimental protocols and&nbsp;data;&nbsp;<strong>ready&nbsp;to deliver presentations</strong>&nbsp;to key stakeholders and leadership&nbsp;on short notice.&nbsp;</li><li>Contribute to <strong>IP and&nbsp;publications</strong>, and&nbsp;help shape program direction with leadership.</li></ul>",
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    "requirements_html": "<p><strong>&nbsp;Education &amp; Experience</strong>&nbsp;</p><ul><li>Ph.D. in cell biology, genomics, genetics, molecular biology, pharmacology,&nbsp;or a related field&nbsp;is&nbsp;strongly&nbsp;preferred.&nbsp;</li><li>2+ years of post-doctoral research or industry experience in drug discovery or early development&nbsp;preferred.&nbsp;</li><li>Significant experience&nbsp;in building&nbsp;one or more&nbsp;projects&nbsp;up&nbsp;from ground zero,&nbsp;demonstrating&nbsp;the capability to troubleshoot high-throughput biology experiments and computational analyses in a&nbsp;<strong>highly&nbsp;independent&nbsp;and&nbsp;driven</strong>&nbsp;manner.&nbsp;</li><li>Significant experience&nbsp;in driving or being a key contributor&nbsp;in&nbsp;one or more&nbsp;<strong>collaborative</strong>&nbsp;projects.&nbsp;</li><li>Strong experience with&nbsp;<strong>mammalian cell culture and&nbsp;cell&nbsp;engineering</strong>.&nbsp;Proficiency&nbsp;with&nbsp;generating stable cell lines using&nbsp;<strong>lentiviral transduction</strong>&nbsp;is&nbsp;required; experience with pooled lentiviral-based genetic screens is preferred.&nbsp;</li><li>Strong direct hands-on&nbsp;experimental&nbsp;experience&nbsp;with&nbsp;at least four&nbsp;of the&nbsp;five&nbsp;key readouts:&nbsp;<strong>flow cytometry, microscopy,&nbsp;transcriptomics,&nbsp;proteomics&nbsp;and microplate readers</strong>, in addition to&nbsp;standard cell and molecular biology techniques (qPCR,&nbsp;RT-PCR, cell viability assays, cloning, western blotting, co-IP experiments, etc.). Capability to&nbsp;design custom next-generation&nbsp;sequencing assays is preferred.&nbsp;</li><li>Deep conceptual understanding and practical&nbsp;know-how&nbsp;of&nbsp;<strong>pharmacological and biochemical&nbsp;experiments</strong>&nbsp;relevant to&nbsp;<em>in vitro&nbsp;</em>characterization and optimization of a therapeutic&nbsp;(e.g., dose response curves,&nbsp;potency&nbsp;and efficacy measurements).&nbsp;&nbsp;</li><li>Experience with&nbsp;<strong>programming in Python</strong>&nbsp;and working&nbsp;in&nbsp;<strong>AWS</strong>&nbsp;for&nbsp;analysis and interpretation of the data you generate.&nbsp;Required to have&nbsp;conceptual&nbsp;understanding of&nbsp;each standard step within&nbsp;routine&nbsp;imaging,&nbsp;genomics&nbsp;and&nbsp;proteomics analysis workflows.&nbsp;&nbsp;</li><li>Familiarity with&nbsp;<em><strong>in vivo&nbsp;</strong></em><strong>experimental design&nbsp;for&nbsp;rodent models</strong>&nbsp;is preferred.&nbsp;</li><li>Excellent data analysis, visualization, and scientific communication skills.&nbsp;</li></ul><p><strong>Nice-to-Haves</strong>&nbsp;</p><ul><li>Experience&nbsp;working&nbsp;with&nbsp;polarized&nbsp;epithelial cell&nbsp;models.&nbsp;</li><li>Experience with&nbsp;the biology of&nbsp;proteins that transport nutrients and electrolytes across the cell membrane.&nbsp;</li><li>Experience with target ID using proteomics.&nbsp;</li><li>Experience with protein expression and purification.&nbsp;</li></ul><p><strong>No matter your role at&nbsp;GondolaBio, successful team members are</strong>&nbsp;</p><ul><li>Patient Champions, who put patients first and uphold strict ethical standards&nbsp;</li><li>Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset&nbsp;</li><li>Truth Seekers, who are detailed, rational, and humble problem solvers&nbsp;</li><li>Individuals Who Inspire Excellence in themselves and those around them&nbsp;</li><li>High-quality executors, who execute against goals and milestones with quality, precision, and speed&nbsp;</li></ul><p><strong>What We Offer</strong>&nbsp;</p><ul><li>Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are&nbsp;seeking&nbsp;to&nbsp;impact&nbsp;throughout the year and learn how we can improve our efforts&nbsp;</li><li>A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak&nbsp;</li><li>An unyielding commitment to always putting patients first&nbsp;</li><li>A&nbsp;de-centralized&nbsp;model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to&nbsp;eliminate&nbsp;bureaucracy and put decision-making power in the hands of those closest to the science&nbsp;</li><li>A place where you own the vision – both for your program and your own career path&nbsp;</li><li>A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game&nbsp;</li><li>Access to learning and development resources to help you get in the best professional shape of your life&nbsp;</li><li>Robust and market-competitive compensation &amp; benefits package (Base, Performance Bonus, Equity, health, welfare &amp; retirement programs)&nbsp;</li><li>Flexible PTO&nbsp;</li><li>Rapid career advancement for strong performers&nbsp;</li><li>Potential ability to work on multiple&nbsp;GondolaBio&nbsp;programs across multiple therapeutic areas over time&nbsp;&nbsp;</li><li>Commitment to Diversity, Equity &amp; Inclusion&nbsp;</li></ul><p>The base pay range for this position is&nbsp;$135,000&nbsp;to $175,000&nbsp;per year.&nbsp;The actual compensation offered will be determined based on&nbsp;a number of&nbsp;job-related factors, including experience, skills, qualifications, and location.&nbsp;A bonus plan and equity will also be offered.&nbsp;</p><p><br></p><p>GondolaBio ServiceCo is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. Employees of BridgeBio and all affiliated companies should work through their managers to inquire about and learn more about this role.</p>",
    "requirements_text": "Education & Experience\n Ph.D. in cell biology, genomics, genetics, molecular biology, pharmacology, or a related field is strongly preferred.\n 2+ years of post-doctoral research or industry experience in drug discovery or early development preferred.\n Significant experience in building one or more projects up from ground zero, demonstrating the capability to troubleshoot high-throughput biology experiments and computational analyses in a highly independent and driven manner.\n Significant experience in driving or being a key contributor in one or more collaborative projects.\n Strong experience with mammalian cell culture and cell engineering . Proficiency with generating stable cell lines using lentiviral transduction is required; experience with pooled lentiviral-based genetic screens is preferred.\n Strong direct hands-on experimental experience with at least four of the five key readouts: flow cytometry, microscopy, transcriptomics, proteomics and microplate readers , in addition to standard cell and molecular biology techniques (qPCR, RT-PCR, cell viability assays, cloning, western blotting, co-IP experiments, etc.). Capability to design custom next-generation sequencing assays is preferred.\n Deep conceptual understanding and practical know-how of pharmacological and biochemical experiments relevant to in vitro characterization and optimization of a therapeutic (e.g., dose response curves, potency and efficacy measurements).\n Experience with programming in Python and working in AWS for analysis and interpretation of the data you generate. Required to have conceptual understanding of each standard step within routine imaging, genomics and proteomics analysis workflows.\n Familiarity with in vivo experimental design for rodent models is preferred.\n Excellent data analysis, visualization, and scientific communication skills.\n Nice-to-Haves\n Experience working with polarized epithelial cell models.\n Experience with the biology of proteins that transport nutrients and electrolytes across the cell membrane.\n Experience with target ID using proteomics.\n Experience with protein expression and purification.\n No matter your role at GondolaBio, successful team members are\n Patient Champions, who put patients first and uphold strict ethical standards\n Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset\n Truth Seekers, who are detailed, rational, and humble problem solvers\n Individuals Who Inspire Excellence in themselves and those around them\n High-quality executors, who execute against goals and milestones with quality, precision, and speed\n What We Offer\n Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts\n A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak\n An unyielding commitment to always putting patients first\n A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science\n A place where you own the vision – both for your program and your own career path\n A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game\n Access to learning and development resources to help you get in the best professional shape of your life\n Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)\n Flexible PTO\n Rapid career advancement for strong performers\n Potential ability to work on multiple GondolaBio programs across multiple therapeutic areas over time\n Commitment to Diversity, Equity & Inclusion\n The base pay range for this position is $135,000 to $175,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.\n GondolaBio ServiceCo is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. Employees of BridgeBio and all affiliated companies should work through their managers to inquire about and learn more about this role."
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