Director/Senior Director, DMPK

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    "html_title": "GondolaBio Service Co, Inc. - Director/Senior Director, DMPK",
    "description_html": "<p>&nbsp;&nbsp;</p><p><u><strong>About GondolaBio</strong></u></p><p><strong>GondolaBio</strong> is a collection of biopharmaceutical companies focused on developing next-generation therapeutics for genetic diseases. Originally carved out of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. GondolaBio aims to leverage cutting-edge biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases.</p><p><br></p><p><u><strong>Who You Are</strong></u></p><p>The primary responsibilities of this position are to serve as a DMPK representative on multi-disciplinary drug discovery teams, provide guidance and support to project teams for candidate selection and clinical trial development, and further characterize the pharmacokinetic and drug metabolism properties of molecules through the development lifecycle of a drug. This individual will have the opportunity to be exposed to a broad spectrum of therapeutic areas across the portfolio.</p>",
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    "requirements_html": "<p>&nbsp;&nbsp;</p><p><u><strong>Responsibilities</strong></u></p><ul><li>Work closely with cross-functional project team members. Participate as a functional representative on clinical trial project teams</li><li>Provide guidance on project teams for candidate selection, develop and drive DMPK strategies and solve ADME-related issues</li><li>Design, coordinate, and interpret in vitro and in vivo DMPK studies</li><li>Determine PK parameters for nonclinical studies using Phoenix WinNonlin and assist with the application of modeling approaches (PK, PKPD) to support human PK and dose predictions</li><li>Support GLP toxicology studies, review toxicokinetic reports, and monitor regulated bioanalysis</li><li>Monitor bioanalytical method development, validation, sample analysis, and review/approve reports</li><li>Generate, analyze and present data, both orally and as written reports</li></ul><p><strong>No matter your role at BridgeBio, successful team members are:</strong></p><ul><li>Patient Champions, who put patients first and uphold strict ethical standards</li><li>Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset</li><li>Truth Seekers, who are detailed, rational, and humble problem solvers</li><li>Individuals Who Inspire Excellence in themselves and those around them</li><li>High-quality executors, who execute against goals and milestones with quality, precision, and speed</li></ul><p><u><strong>Education, Experience &amp; Skills Requirements</strong></u></p><ul><li>PhD or Pharm D. in Pharmacokinetics, Pharmaceutical Sciences, or related field &nbsp;with a specific focus on small molecule pharmacokinetics and metabolism &nbsp;with at least 5 years of relevant industry experience</li><li>Strong understanding of DMPK principles and drug development processes</li><li>Expertise &nbsp;in drug metabolism is desirable</li><li>Hands-on &nbsp;experience using pharmacokinetic data analysis software such as Phoenix WinNonlin</li><li>Able to work independently and possess excellent interpersonal skills</li><li>Possess effective problem-solving, oral, and written communication skills</li></ul><p><u><strong>What We Offer</strong></u></p><ul><li>Patient &nbsp;Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts</li><li>A &nbsp;culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak</li><li>An unyielding commitment to always putting patients first. Learn more about how we do this <a href=\"https://bridgebio.com/about\">here</a></li><li>A de-centralized model that enables our program teams to focus on advancing &nbsp;science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science</li><li>A place where you own the vision – both for your program and your own career path</li><li>A collaborative, fast-paced, data-driven environment where we inspire &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ourselves and each other to always perform at the top of our game</li><li>Access to learning and development resources to help you get in the best professional shape of your life</li><li>Robust &nbsp;and market-competitive compensation &amp; benefits package (Base, Performance Bonus, Equity, health, welfare &amp; retirement programs)</li><li>Flexible &nbsp;PTO</li><li>Rapid career advancement for strong performers</li><li>Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time&nbsp;</li><li><a href=\"https://bridgebio.com/partners\">Partnerships with leading institutions</a></li><li>Commitment to Diversity, Equity &amp; Inclusion</li></ul><p>&nbsp; &nbsp;</p><p>\"GondolaBio ServiceCo is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. Employees of BridgeBio and all affiliated companies should work through their managers to inquire about and learn more about this role.\"</p><p><br></p><p>The base pay range for this position is $255,000 to $285,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.&nbsp;&nbsp;</p><p>&nbsp;&nbsp;</p>",
    "requirements_text": "Responsibilities\n Work closely with cross-functional project team members. Participate as a functional representative on clinical trial project teams\n Provide guidance on project teams for candidate selection, develop and drive DMPK strategies and solve ADME-related issues\n Design, coordinate, and interpret in vitro and in vivo DMPK studies\n Determine PK parameters for nonclinical studies using Phoenix WinNonlin and assist with the application of modeling approaches (PK, PKPD) to support human PK and dose predictions\n Support GLP toxicology studies, review toxicokinetic reports, and monitor regulated bioanalysis\n Monitor bioanalytical method development, validation, sample analysis, and review/approve reports\n Generate, analyze and present data, both orally and as written reports\n No matter your role at BridgeBio, successful team members are:\n Patient Champions, who put patients first and uphold strict ethical standards\n Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset\n Truth Seekers, who are detailed, rational, and humble problem solvers\n Individuals Who Inspire Excellence in themselves and those around them\n High-quality executors, who execute against goals and milestones with quality, precision, and speed\n Education, Experience & Skills Requirements\n PhD or Pharm D. in Pharmacokinetics, Pharmaceutical Sciences, or related field with a specific focus on small molecule pharmacokinetics and metabolism with at least 5 years of relevant industry experience\n Strong understanding of DMPK principles and drug development processes\n Expertise in drug metabolism is desirable\n Hands-on experience using pharmacokinetic data analysis software such as Phoenix WinNonlin\n Able to work independently and possess excellent interpersonal skills\n Possess effective problem-solving, oral, and written communication skills\n What We Offer\n Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts\n A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak\n An unyielding commitment to always putting patients first. Learn more about how we do this here\n A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science\n A place where you own the vision – both for your program and your own career path\n A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game\n Access to learning and development resources to help you get in the best professional shape of your life\n Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)\n Flexible PTO\n Rapid career advancement for strong performers\n Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time\n Partnerships with leading institutions\n Commitment to Diversity, Equity & Inclusion\n \"GondolaBio ServiceCo is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. Employees of BridgeBio and all affiliated companies should work through their managers to inquire about and learn more about this role.\"\n The base pay range for this position is $255,000 to $285,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered."
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