Senior Director, Clinical Research (Oncology)

Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN ® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies. Vir Biotechnology has exclusive rights to the universal PRO-XTEN ® masking platform for oncology and infectious disease. PRO-XTEN ® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company. We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best. THE OPPORTUNITY The Senior Director, Clinical Research Oncology will provide strategic and operational leadership for the Clinical Science function within Oncology Clinical Development. You will be accountable for shaping and executing clinical development strategies across oncology programs, ensuring scientific rigor, regulatory alignment, and efficient delivery of high‑quality clinical data. This role requires an experienced MD, PhD or PharmD with deep expertise in oncology drug development and a proven track record of leading clinical research teams through complex development programs, from first‑in‑human through registration. WHAT YOU'LL DO Clinical Science & Development Leadership Serve as the Clinical Science functional leader for one or more oncology programs across early and/or late‑stage development. Define and drive clinical development strategies, including indication selection, study design, endpoints, and lifecycle planning. Provide clinical and scientific leadership across all phases of development, including Phase 1, dose expansion, registrational, and post‑approval studies. Ensure integration of clinical, translational, pharmacology, biometrics, and regulatory perspectives into cohesive development plans. Study & Program Oversight Oversee clinical science deliverables for assigned studies, including protocols and amendments, informed consent forms (ICFs), case report form (CRF) design and data review strategies, and clinical study reports (CSRs) as well as the clinical sections of regulatory submissions. Guide ongoing clinical data review, interpretation, and risk assessment, escalating key findings and safety signals as appropriate. Partner closely with Clinical Operations to ensure high‑quality study execution, timelines, and decision‑ Cross ‑ Functional & Governance Leadership Act as the clinical science representative on program teams, clinical development sub‑teams, and governance forums. Drive alignment and decision‑making across Clinical Operations, Biometrics, Translational Medicine, Clinical Pharmacology, Regulatory, Safety, and Medical Writing. Present and defend clinical strategy and data to internal governance committees, executive leadership, and external stakeholders. External Engagement Serve as a key scientific interface with investigators and key opinion leaders (KOLs), advisory boards and steering committees, and regulatory agencies, as needed. Support preparation for and participation in regulatory interactions and scientific meetings. People & Functional Leadership Lead, mentor, and develop clinical scientists, fostering scientific excellence, accountability, and career growth. Contribute to building and scaling the Clinical Science function, including process development, talent strategy, and best practices. WHO YOU ARE AND WHAT YOU BRING MD, PhD, or PharmD in a relevant scientific or medical discipline (e.g., Oncology, Immunology, Pharmacology, Molecular Biology). 12+ years of experience in oncology clinical research and drug development in a pharmaceutical, biotechnology, academic, or CRO environment. Demonstrated experience leading both early‑ and late‑stage clinical development programs. Proven ability to serve as a clinical science or program lead, with accountability for strategy and execution. Experience contributing to or leading regulatory submissions and interactions is strongly preferred. Demonstrate a deep understanding of oncology clinical trial design and execution, GCP/ICH guidelines and regulatory expectations, and clinical data interpretation, safety evaluation, and benefit‑risk assessment. Strong knowledge of translational and biomarker strategies that inform clinical development decisions. Collaborative leader with a track record of effective cross‑functional partnership #LI-AS1 #LI-Onsite WHO WE ARE AND WHAT WE OFFER The expected salary range for this position is $235,500 to $329,500 per year. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors. Vir Biotechnology's compensation and benefits are aligned with the current market and commensurate with the person’s experience and qualifications. All full-time employees receive a package that includes compensation, bonus and equity as well as many other Vir Biotechnology benefits and perks such as health and welfare benefit plans, non-accrual paid time off, company shut down for holidays, commuter benefits, 401K match and lunch each day in the office. Applicants must currently be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time. All employment decisions at Vir Biotechnology are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications. Employment decisions are made without regard to any legally protected characteristics. This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs. Vir Biotechnology also strongly commits to providing employees with a work environment free of unlawful conduct or harassment. Vir Biotechnology Human Resources leads recruitment and employment for Vir Biotechnology. Unsolicited resumes sent to the company from recruiters do not constitute any type of relationship between the recruiter and Vir Biotechnology and do not obligate us to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees. For hires based in the United States, Vir Biotechnology, participates in E-Verify . Candidate Privacy Notice

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