Senior Clinical Research Scientist II

Caribou Biosciences is a leading clinical-stage CRISPR genome-editing biopharmaceutical company dedicated to developing transformative therapies for patients with devastating diseases. Our next-generation genome-editing technology enables superior precision to develop cell therapies that are armored to potentially improve activity against diseases. We believe the future of cell therapy is off-the-shelf, and we are advancing our pipeline of off-the-shelf, or allogeneic, cell therapies from our CAR-T cell therapy platform as readily available treatments for patients with hematologic malignancies and autoimmune diseases. Members of the Caribou herd open their minds to new ideas and welcome diverse perspectives. We proudly assert that teams do their best work when their members are personally engaged, their ideas are taken seriously, and contributions are recognized. Members of the herd work from our headquarters in Berkeley, California, or remotely. Summary : The Senior Clinical Research Scientist II plays a key role in the clinical development of allogeneic CAR-T therapies for hematologic malignancies, including lymphoma, leukemia, and multiple myeloma. They are responsible to lead study-level activities and contribute to clinical strategy, driving the design, execution, and interpretation of early-phase clinical trials. The candidate is expected to partner cross-functionally to ensure high-quality data generation, advance innovative therapies, and support regulatory submissions. Responsibilities : Lead clinical study in execution, including planning, conduct, data review, and reporting for Phase I and II trials in hematologic malignancies Own ongoing clinical data review, ensuring patient safety and data integrity; identify trends and drive data informed decisions Lead safety monitoring activities including review of adverse events and CAR-T associated toxicities (ie: CRS, ICANS) and contribute to dose escalation decisions Drive cross-functional collaboration with Clinical Operations, Translational Sciences, Data Management, Biostatistics, Regulatory, and CMC teams to ensure high-quality study execution Lead authorship of key study documents, including protocols, Investigator’s Brochures, clinical study reports, regulatory documents, and safety narratives Integrate clinical and translational data (ie: cell expansion, persistence, biomarker data) to generate insights and inform program strategy Contribute to regulatory strategy and submissions, including IND-related documents and health authority responses Serve as a scientific lead at the study level, engaging with investigators, CROs, and key opinion leaders Support development of publications, abstracts, and presentations for scientific conferences Ensure compliance with GCP, internal SOPs, and regulatory requirements Qualifications : PhD/PharmD with 5+ years of experience in clinical development; MA/MS/MSN and 8+ years of experience; BA/BS/BSN and 10+ years of experience Experience in hematology-oncology drug development Experience with CAR-T or cell therapy development Demonstrated ownership of clinical studies, preferably early phase trials Strong scientific writing and communication skills Experience with GCP and regulatory requirements Experience with clinical data review and interpretation (including data listings) Ability to analyze and synthesize complex clinical and biomarker data Ability to travel 30% based on business needs Nice-to-haves: Experience in fast paced biotech environment Experience with product launch or late stage development activities Caribou compensation and benefits include: Comprehensive compensation package, which includes competitive salary, bonus, and equity for all employees Salary Range: $215,000 - $230,000. This represents the present low and high end of the Company’s pay range for this position. Actual pay will vary based on various factors, including but not limited to location, skill, experience, and performance. Generous paid vacation time, in addition to company-observed holidays Excellent medical, dental, and vision insurance 401(k) retirement savings plan, which includes matching employer contributions Employee stock purchase plan (ESPP) Tuition reimbursement program The benefits and stock purchase described above are subject to the terms and conditions of any governing plans, policies, practices, agreements, or other materials or documents as in effect from time to time, including but not limited to terms and conditions regarding eligibility. Caribou is an equal opportunity employer and does not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws. Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. We do not accept unsolicited resumes or candidate submissions from staffing agencies. All agencies must have a valid written agreement with Caribou Biosciences, Inc. for service in place. Any resume or candidate submitted by a staffing agency without such an agreement in place will be considered unsolicited, and Caribou Biosciences, Inc. will not be obligated to pay any referral or placement fee.

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