Vice President, Product Strategy

About Us Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world. It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve. Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020. We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients. At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families , we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic —leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn , we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries. These values are the foundation of our work, empowering us to make a real difference, every day. Position Title: Vice President, Product Strategy Department: Product Strategy Reports To: Chief Strategy Officer Location: South San Francisco, CA or Princeton, NJ or Chicago, IL – On-site 4 days per week (Mon to Thurs) Job Overview The Vice President, Product Strategy will play a key role in defining and driving the end-to-end product strategy across the Kardigan’s portfolio. The successful individual sits at the intersection of science, clinical development, commercial, and corporate strategy, translating pipeline assets into clear product visions, value propositions, and lifecycle strategies that maximize patient impact and enterprise value. The VP Product Strategy partners closely with Global Program Heads (GPHs) to ensure product strategy decisions are grounded in rigorous data, differentiated positioning, and long-term portfolio value creation. This includes working across Clinical Development, Medical Affairs, Regulatory, Commercial, and Business Development functions. The VP Product Strategy will lead a team of individuals who serve as either product strategy leads for individual products or as centralized capability groups (“CoEs”) such as competitive intelligence, forecasting and market access. Essential Duties and Responsibilities Product Positioning & Development Plan Support Lead the development and ongoing evolution of integrated product strategies across all pipeline and marketed assets, from early clinical stages through lifecycle management. Prioritize product expansion opportunities, and recommend timing (e.g., when to initiate new programs) Define and continue to refine the strategy for global commercialization of the portfolio Define target product profiles (TPPs), value propositions, and differentiation strategies informed by unmet need, competitive landscape, and clinical data. Partner with Clinical Development and Medical to influence trial design, endpoints, and evidence generation aligned to product and commercial goals. Drive scenario planning and trade-off decisions across indications, lines of therapy, geographies, and lifecycle opportunities. Lead competitive intelligence and market landscaping to inform strategic choices and risk mitigation Investment Decision-Making Serve as a strategic advisor to the Chief Strategy Officer, GPHs and Chief Executive Officer on product- and portfolio-level decisions. Support the GPHs in developing recommendations for program-related investments (stage-gate decisions, new indications, new formulations, development plan modifications, etc.) Work closely with the portfolio management team to ensure a quality and timely factbase for portfolio decision-making, and appropriate framing / communication of recommendations for Kardigan’s portfolio governance mechanisms Support business development activities including asset evaluation, diligence, and integration of acquired programs into the portfolio. Launch Planning Create and own the overall cross-functional launch plan Drive decision-making and execution on the activities that are most critical for successful product launches Partner with Commercial to ensure launch readiness, positioning, and lifecycle strategies are cohesive and evidence-based. Collaborate with Regulatory and Market Access to anticipate approval pathways, pricing considerations, and reimbursement dynamics. Team & Capability Building Define required CoEs and plan / timeframe to build these out; lead hiring and talent development of the CoEs Ensure CoEs are appropriately supporting both of global product teams and our business development activities Manage and mentor product strategy leads; provide guidance on most critical issues across the portfolio Qualifications and Preferred Skills Education: Advanced degree preferred (PhD, MD, PharmD, MBA), with strong scientific literacy required. Experience: 12+ years of experience in biotech, pharma, or life sciences consulting with progressive leadership responsibility. Demonstrated experience leading product strategy across clinical development stages; pre-launch and launch experience strongly preferred. Proven experience working cross-funcdtionally across R&D, Commercial, Regulatory, and Market Access Prior involvement with launch readiness, pricing and reimbursement planning, and evidence generation strategy development. Experience building and scaling a product strategy function, including team development, governance frameworks Deep understanding of clinical development, regulatory pathways, competitive dynamics, and commercialization considerations. Knowledge/Skills/Abilities: Proven ability to lead workstreams and influence cross-functionally to drive alignment without direct authority Ability to lead and manage a product strategy team Strong strategic and technical understanding; strong analytical skills and ability to anticipate operational issues and risks, and to proactively recommend mitigations and solutions Strong skills in strategic framing and communication via PowerPoint presentations Initiative/self-starter with a continuous improvement mindset and demonstrated experience managing across multiple functions and teams Strong work ethic with a sense of urgency and demonstrated ability to consistently deliver high quality output Excellent written and oral communication skills; comfortable interacting and communicating with individuals at all levels of the organization Detail oriented with ability to manage multiple priorities Strong sense of resilience and comfortable operating in a fast-paced, dynamic, start-up environment Flexibility to travel as needed; spending time periodically with functional and program leaders and teams as well as overall corporate leadership located in SSF, Chicago and Princeton will be required Exact Compensation may vary based on skills, experience and location. Pay range $313,000 — $377,000 USD

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