Senior Cloud Engineer

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale. Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges. Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX. Together we are moving psychiatry forward—beyond better, into a boundless future. Join us! Definium Therapeutics is seeking a Senior Cloud Engineer to drive the design, build, and operations of scalable, secure, and automated cloud solutions across the enterprise. This role is highly tactical, focused on day-to-day execution that directly impacts business operations, while ensuring alignment with long-term IT architecture, security, and regulatory requirements. The Senior Cloud Engineer will serve as a critical interface between IT engineering, AI/ML teams, software development, data system owners, and business stakeholders, translating business requirements into scalable, compliant, and repeatable technical solutions. This role plays a key part in advancing cloud infrastructure, enabling intelligent automation, supporting system integrations, and ensuring operational excellence across Definium’s technology ecosystem. Responsibilities Design deploy maintain optimize and automate scalable secure and resilient cloud infrastructure and solutions across Azure GCP and AWS Manage backup and disaster recovery strategies across cloud platforms Implement and maintain robust cloud security controls aligned with industry standards CIS NIST and ISO 27001 Implement and maintain Infrastructure as Code cloud automation and CI CD driven deployments Support cloud automation initiatives including infrastructure automation integrations operational workflows and platform stability improvements Enable AI and intelligent automation use cases in alignment with established governance and security standards Troubleshoot cloud platform issues support incident resolution and maintain technical documentation and runbooks Help define and enforce cloud governance standards including management groups subscriptions Azure Policy RBAC naming conventions tagging and cost controls Implement automation in ServiceDesk identity and other enterprise platforms to drive consistent efficient and rapid experiences Engage with IT and functional stakeholders to define business processes align them to appropriate technology solutions and represent Definium technology interests on initiatives with significant technology impact Translate functional and technical requirements into solution architecture and provide build and deployment guidance to software developers Design scalable supportable systems by selecting technology stacks that can be supported by a broad ecosystem of providers and technically skilled Definium staff Identify and evaluate technology partners and maintain relationships with strategic vendors to stay informed of evolving capabilities and risks Stay current on leading and emerging technologies and evaluate fit against financial security and operational requirements Cross train and mentor junior engineers Qualifications Bachelor's degree in Information Systems, Engineering, Business Administration, Computer Science, or related field. MBA or advanced degree preferred Minimum 8 years of experience in engineering, infrastructure, or operations roles, preferably in a regulated industry Experience with public cloud platforms (Azure, AWS, or GCP) Strong expertise in cloud architecture, networking, and security best practices Experience with multi-cloud environments and cloud migrations Proficiency in scripting languages such as Python and PowerShell Experience implementing enterprise integrations. (APIs, middleware, event-driven systems) Experience working within a Microsoft enterprise environment, including: Microsoft 365 (M365 / O365 Entra ID Exchange Online SharePoint Online Experience with Robotic Process Automation (RPA) and low-code/no-code platforms. (e.g., Microsoft Power Platform) Familiarity with serverless computing. (Azure Functions, AWS Lambda, Google Cloud Functions) Experience integrating SaaS applications using middleware platforms Cloud architecture certifications such as Azure Solutions Architect (preferred), AWS Certified Solutions Architect, or Google Professional Cloud Architect The starting base pay range for this position is $132,400,00- $170,864.00. Compensation will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location. Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including: 100% paid health benefits including Medical, Dental and Vision for you and your dependents 401(k) program with company match and vesting after the turn of the first month after your start date Flexible time off Generous parental leave and some fun fringe perks!

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