Pioneering Medicines: Director / Senior Director, Metabolics Research

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner? About Pioneering Medicines: Pioneering Medicines, Flagship Pioneering’s in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship’s innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship’s bioplatform companies. Within Flagship’s Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners’ R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. Position Summary: Pioneering Medicines is seeking an ambitious, innovative and highly collaborative leader (Director or Senior Director level) to join our Metabolic Diseases Research team. The candidate should demonstrate depth and breadth of experience in delivering impactful biology data that shapes the direction of drug discovery and/or early clinical programs. The ideal candidate will have a deep understanding of laboratory techniques and assays, biology/translational sciences expertise, and strong leadership, interpersonal, and communication skills to be able to lead cross-functional Program teams, typically in collaboration with one or more companies. In this role, the candidate will manage a Research team and partner across Pioneering Medicines providing therapeutic area expertise in obesity, diabetes, liver disease, and related metabolic diseases. The candidate will also be expected to lead a Program team at various stages from Target ID/validation through clinical candidate delivery and preclinical development. The ideal candidate will have recognized expertise in laboratory techniques and assays, significant experience in target ID/validation, as well as a strong understanding of the intricacies of early drug development. Affinity for technologies leading to the discovery of new medicines is also essential (e.g., genomics, transcriptomics, network/systems biology, and/or machine learning). Key Accountabilities: Provide therapeutic expertise to guide research strategy, experimental design, and translational approaches across metabolic disease programs Bring visionary scientific thought and leadership to PM to enable the company to progress with its innovative approaches Serve as Program Leader or Research Leader in advancing specific drug discovery and development Programs at various stages from Target ID through delivery of a clinical candidate and preclinical development As Program leader, serve as the single point of accountability to Program stakeholders, including Senior Leaders at PM and Flagship collaborating companies, and Pharma partners for guiding research project strategy and progress Lead early drug projects in the metabolic disease space, propose and champion new targets and novel approaches for disease treatment Design and execute in vitro and in vivo research plans to evaluate targets modulating pathways in the broad area of metabolic diseases Guide assay development and implementation of new technologies to enable the delivery of high-quality data packages for project go/no-go decisions in portfolio transitions Collaborate with other scientists in the PM/Flagship ecosystem in a global matrixed environment fostering innovation to advance project activities. Develop and maintain external relationships/contacts Qualifications: PhD or MD/PhD with experience in the prescribed scientific areas Metabolic disease expertise with a focus on obesity, diabetes, and liver disease Inflammation or Cardiovascular expertise desired, not required 12+ years of experience in the biopharmaceutical industry Experience in drug discovery/early development through oversight of multiple programs. Experience with modalities like peptides and antibodies is highly desired. Proven track record of providing scientific expertise and developing strategies to address unmet needs Recognized expert in relevant biology, with an impeccable scientific pedigree Strong interpersonal communication skills with ability to inspire, build, and develop high-performing teams of scientists Exhibit strong drive for achievement and success while showcasing respect and care of people Demonstrate sound business judgment with an ability to evaluate alternatives, establish priorities, and apply resources effectively Track record of working seamlessly and building relationships with other functions across the organization About Flagship Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company’s annual list of the World’s Most Innovative Companies. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $172,000 - $280,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future. Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [email protected].

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