Head of Product/Portfolio Management

About Genetix Biotherapeutics At Genetix Biotherapeutics every role has meaning, every team member is respected, and every day is a chance to make a difference. When you join Genetix, you're not just landing a new role, you become part of a company that's pursuing curative gene therapies to give patients and their families more days. We are doers, thinkers and collaborators who embrace and live by our values: Our innovation is rooted in the diversity of our teams and results are achieved through cooperation and the integration of multiple viewpoints. This is personal and we approach every challenge with radical care. SUMMARY The Head of Product/Portfolio Management is a strategic leader for Genetix’ two FDA approved genetic therapies for the treatment of hemoglobinopathies. You will be responsible for establishing the long-term product strategy while enabling teams to achieve execution of lifecycle management plans. You will provide cross-functional leadership across drug development and lifecycle management execution to maximize long-term value for two commercial stage products. You will drive achievement of product goals and advancing Genetix’s leadership in transforming lives through curative therapies. The ideal candidate will be a strategic leader well-versed in drug development and commercial execution and a strong influencer who can integrate effectively while aligning stakeholders across different functions and levels of the organization. Reporting to the Chief of Staff & Head of Corporate Development and Strategy, you will champion critical portions of Genetix’s leading assets with significant executive visibility and potential for patient impact. RESPONSIBILITIES Lead the cross-functional team consisting of senior leaders in Commercial, CMC, Regulatory, Medical, and Clinical, responsible for setting and achieving product vision and strategy Incorporate the long-term vision to develop, optimize, and execute lifecycle management plans Drive the development and execution of the integrated cross-functional strategic and operational product plan and timelines Integrate cross-functional perspectives, ensuring technical rigor, emerging data, competition, and the evolving landscape in key markets are incorporated routinely to inform product direction Partner with functional leads and senior leadership to set product goals aligned with corporate goals Foster strong cross-functional team performance, empowering the team while driving alignment, accountability, prioritization, and timely decision making to deliver on product goals Proactively anticipate issues and ensure contingency plans are put in place; identify barriers and problem-solve to mitigate them; identify opportunities and how to capture them Establish clear product communications and deliver critical updates between teams and senior leaders, ensuring strategic alignment and awareness of changes to strategy or timelines Partner with corporate communications and the Executive Team to develop product communication strategies, positioning, and messaging Drive innovation and maximize long-term value creation by challenging the status quo QUALIFICATIONS 10+ years of industry experience with 5+ years leading drug development programs/products or in life sciences consulting BA/BS degree required, advanced degree preferred (MBA, PharmD, PhD, MD) Deep understanding of drug development & commercialization Cell and gene therapy, rare disease, and hemoglobinopathy experience strongly preferred Fully and consistently demonstrates strong communication skills across all levels and functions – able to succinctly summarize complex issues (verbally and in writing) to move team forward An authentic leader who builds and maintains strong relationships and trust, with exceptional ability to influence key stakeholders at all levels in a matrix environment Ability to inspire, empower and motivate teams without direct authority to cultivate high performance by creating an environment that invites diverse perspectives, continual improvement, and opportunistic thinking A strong collaborator who communicates in an open, direct, and timely manner Flexibility and the ability to nimbly adapt to changing conditions Motivated by patient focus and personal commitment to high performance and results Possesses high integrity and exceptional work ethic Strong experience with program management best practices Advanced PowerPoint efficiency Additional Information The pay transparency range provided below is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. We may ultimately pay more or less than the posted range, and the range may be modified in the future. This role is eligible for an annual bonus and long-term incentive. Actual base salary pay will be based on several factors, including but not limited to experience, skills, relevant education/qualifications, external market, internal equity, and other job-related factors permitted by law. Genetix’s total rewards package also provides employees with a comprehensive and competitive benefits suite to support a variety of employee needs. These benefits include comprehensive health, life and disability insurance, employer-matched 401(k) plan, lifestyle spending account, flexible time-off + paid holidays and winter holiday period, tuition reimbursement & loan repayment assistance, paid parental leave, paid onsite parking, commuter subsidy, and much more. Pay Transparency $263,000 — $323,000 USD Genetix is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.

{
  "content_hash": "a1f0d624e6890e09844bdc68e3fa8424d9474cd80f439023be0fb1ff6e55e651",
  "source_hash": "489fbe11ad3e8a297b951d3b0d74c3235542fc71f07fcb00d871e82768e6dcdb",
  "last_changed_at": "2026-05-29T23:00:37.044Z",
  "active_status": "active"
}

{
  "language": "en",
  "location": {
    "raw": "Somerville, Massachusetts",
    "city": "Somerville",
    "region": "MA",
    "country": "United States",
    "is_remote": false,
    "confidence": 0.85
  },
  "salary_max": null,
  "salary_min": null,
  "inferred_at": "2026-06-18T07:35:54.407Z",
  "launch_scope": {
    "reason": "english_us_canada",
    "included": true,
    "language": "en",
    "location": {
      "raw": "Somerville, Massachusetts",
      "city": "Somerville",
      "region": "MA",
      "country": "United States",
      "is_remote": false,
      "confidence": 0.85
    },
    "countries": [
      "United States"
    ]
  },
  "remote_policy": null,
  "salary_period": null,
  "workplace_type": "on_site",
  "salary_currency": null
}

{}

{
  "title": "Head of Product/Portfolio Management ",
  "offices": [
    {
      "id": 86122,
      "name": "Somerville",
      "location": "Somerville, Massachusetts, United States",
      "child_ids": [],
      "parent_id": null
    }
  ],
  "language": "en",
  "location": {
    "name": "Somerville, Massachusetts"
  },
  "metadata": [],
  "updated_at": "2026-05-15T08:52:52-04:00",
  "departments": [
    {
      "id": 346672,
      "name": "Business Operations",
      "child_ids": [],
      "parent_id": 346671
    }
  ],
  "company_name": "Genetix Biotherapeutics",
  "requisition_id": 3362291,
  "first_published": "2026-02-13T12:38:04-05:00",
  "application_deadline": null
}