Associate Scientist III, Quality Control

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position This position is within the Quality Control structure, under the Quality Organization. An Associate Scientist III, Quality Control will support the analytical testing of Environmental monitoring samples, pharmaceutical raw materials, in-process samples, finished drug substances and drug product, and/or stability sample testing activities for new drug substances and drug products. The Associate Scientist III will also support testing required for GLP Toxicology and cGMP Clinical Trial material release, as well as stability studies. The Associate Scientist III is expected to perform several analytical techniques and can make sound scientific decisions under guidance from management. This position reports to QC Laboratory Management. Responsibilities Developing understanding and knowledge of cGMP requirements. With guidance from laboratory leadership, works to meet project timelines and deliverables Performs routine analytical testing of pharmaceutical raw materials, in-process samples, finished products and/or stability samples using established test methods and procedures Executes training requirements, applies relevant SOPs and associated procedural guides Ensures that training records are up to date and in compliance Proficient with various analytical instrumentation theory and practice Trains on, and becomes proficient with, a variety of analytical instrumentation (e.g., HPLC, GC, FT-IR, UV/Vis, KF, etc.) Can set up various instrumentation for testing according to written test methods with little to no supervision Plans and executes work related tasks with minimal supervision Performs analyses in a timely manner Works collaboratively with others Shows initiative and interest in learning new techniques and tests Identifies and troubleshoots analytical problems with instrumentation, general chemistry and computer applications Quickly communicates analytical or sample issues to senior staff and/or management Maintains a clear, concise and accurate laboratory notebook or worksheet records. Reviews test data acquired by others, as applicable. Drafts technical documents such as OOS/atypical investigations, deviations and CAPAs Demonstrates good written and verbal communication skills Proficient in analyzing data/results and interpret outcome of experiments and to propose appropriate follow-up with supervision. Embraces cGMP requirements for all associated work Works cooperatively in a team environment Establishing attention to detail Calibration, maintenance, and troubleshooting of analytical equipment with limited supervision. Remains flexible with changing priorities Requirements: B.S. in Chemistry (or related field) with 3-5 years of relevant laboratory experience Knowledgeable of cGMP laboratory requirements and operations Familiar with analytical instrumentation, test methodology/validations, data acquisition systems, and typical cGMP policies and practices. Wisconsin pay range $80,000 — $100,000 USD Arrowhead provides competitive salaries and an excellent benefit package. Candidates must have current, valid authorization to work in the country where this role is located. California Applicant Privacy Policy

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