Senior Director, Clinical Development

Company Overview Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been submitted to the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-3050, an IND-cleared FAP-targeted radiotherapy; and IM-1617, an IND-cleared solid tumor ADC. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets. Position summary: We are seeking an accomplished Senior Director, Clinical Development to join our passionate and collaborative team and drive the advancement of our pipeline of targeted cancer therapies. In this high-impact role, you will lead clinical strategy and execution within our innovative portfolio of ADC and radioligand therapies across all stages of development. Key Responsibilities: Lead and execute the clinical development strategy for novel oncology therapies. Collaborate with internal and external stakeholders to design and implement a clinical development plan across indications. Author/lead key clinical trial documents and clinical sections of regulatory filings such as pre-INDs and INDs. Serve as the primary Medical Monitor for assigned programs, including overseeing internal and external teams and providing medical guidance to CRO partners and clinical sites. Support safety monitoring and pharmacovigilance activities. Collaborate cross-functionally with clinical operations, regulatory, project management, manufacturing, and business development to define timelines, manage risks, and ensure milestone delivery. Work closely with translational sciences to integrate key biomarker and pharmacodynamic endpoints into clinical study designs Establish and maintain strong relationships with PIs, KOLs and other external stakeholders. Review, assess, interpret, and communicate clinical trial data to internal stakeholders and external partners. Lead clinical trial data publication efforts. Facilitate key meetings such as advisory boards, safety review committees, investigator meetings. Qualifications: M.D., D.O. or equivalent. Board certification in medical oncology or hematology preferred. A minimum of 2-4+ years of experience leading Clinical Development and Phase 1 – 3 oncology clinical trials in a biotech or pharmaceutical setting. Knowledge and Skills Proven experience advancing therapeutic programs from IND-enabling studies through early and late-stage clinical development Understanding of FDA and EMA regulatory requirements and successful track record in regulatory interactions Demonstrated leadership and ability to effectively manage cross-functional teams Washington State Pay Range $342,561 — $389,125 USD E/E/O Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. E-Verify Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish) .

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