Senior Scientist - Medicinal Chemistry

Senior Scientist - Medicinal Chemistry Location: The Woodlands, TX - Onsite Company Nurix Therapeutics. is a science-focused organization that is committed to bringing novel, first-in-class therapies to patients. We are a leader in discovering new classes of drugs that work by modulating the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation – a function vital to the healthy life of a cell – offering therapeutic opportunities in multiple disease areas. The Nurix scientific team has established an innovative drug discovery platform to identify selective inhibitors or activators of the UPS, enabling the development of new class of drugs that can restore normal cellular homeostasis. Nurix was founded by internationally recognized experts in the UPS field. Nurix is based in Brisbane, California, with an additional facility in The Woodlands, TX About the Position We are seeking talented and highly motivated individuals with a strong background in synthetic organic chemistry to join our medicinal chemistry group in the pursuit of novel small molecules to treat patients with unmet medical needs. The successful candidate will engage in rational structure-based drug discovery enabled by our computational and structural biology group. Specifically, this individual will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy. As members of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix and with external collaborators. Additionally, they will contribute effectively to patent, report and scientific publication writing. Qualifications · BS or MS in degree with 8+ years pharmaceutical medicinal chemistry industrial experience; or a  Ph.D. in synthetic organic chemistry with 6+ years pharmaceutical medicinal chemistry industrial experience. · Deep expertise in synthetic organic and medicinal chemistry, with a strong track record of creatively solving complex synthetic and medicinal chemistry challenges to advance discovery programs. · Proven application of structure-based drug design and molecular modeling, including effective use of cheminformatics, visualization, and conformational analysis tools, in close collaboration with computational chemists to advance leads and deliver development candidates. · Strong understanding of drug discovery principles, including SAR, ADME, pharmacology, and target biology, with the ability to integrate multidisciplinary data to drive programs through candidate selection. · Excellent communication skills, including the ability to clearly present scientific rationale, key data, and program accomplishments to diverse audiences, while effectively gathering and synthesizing competitive intelligence from patents and scientific meetings. · Demonstrated leadership in cross-functional settings as project lead or co-lead, with the ability to guide medicinal chemistry strategy and execution to achieve key project milestones. Fit with Nurix Culture and Values • Strong team orientation; highly collaborative • Solutions and results-oriented focus • Hands-on approach; resourceful and open to diverse points of view Location: The Woodlands, Texas Salary Range: $138,309 – $157,498 + Bonus and Equity Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy ( https://www.nurixtx.com/privacy-policy/ ).

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