Scientist I, In Vivo Pharmacology

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          "text": "<p>Our expanding In Vivo Tumor Biology group in Lake County, IL is hiring a motivated tumor biologist dedicated to discovering and developing innovative small-molecule and biologic therapeutics. The position will focus on tumor-targeting biologics including ADCs and T-cell engager (TCE) therapeutics in both immunocompromised and humanized mouse models. Our scientists collaborate with in vitro biology, translational/biomarker, and medicinal chemistry teams to advance oncology agents through the R&amp;D pipeline. The position is within a dynamic, collaborative research team passionate about advancing novel science and improving patients' lives</p><p>The successful candidate will have expertise in designing and executing studies using tumor models in both immunocompromised and immunocompetent mice. Excellent communication skills and a willingness to work with a multidisciplinary team of researchers are essential.</p><p>Strong candidates have experience in ADC and TCE therapeutics and familiarity with humanized mouse studies.</p><p><strong>Core Responsibilities:</strong></p><ul><li>Independently execute, monitor, and interpret in vivo mouse cancer studies (e.g. CDX, PDX, disseminated, syngeneic)</li><li>Evaluate novel cancer therapeutics in vivo through efficacy, PK, and tolerability studies.</li><li>Collect and prepare tissue from in vivo tumor studies for PD analysis in downstream applications, including IHC, flow cytometry, and RNAseq</li><li>Identify, validate and utilize humanized mouse models to support Abbvie pipeline assets.</li><li>Interpret results and draw conclusions from own multistage experiments and suggest, design, and pursue relevant experiments that further project goals.</li><li>Perform routine and complex tasks competently and independently. May innovate new experimental protocols/techniques.</li><li>Appetite for developing novel in vivo approaches and models to address complex biological questions.</li></ul>",
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          "text": "<ul><li>BS with 5+ years of experience or MS 2+ years with a degree in physiology, pharmacology, molecular biology or any related field of biology is required.</li><li>Strong technical expertise in in vivo experimentation, including health monitoring, tumor implantation (subcutaneous, disseminated etc.), tumor measurements, dosing via IP, IV, SC, PO routes, and blood/tissue collection.</li><li>Familiarity with huPBMC and CD34 humanized mice is highly desired.</li><li>Experience with mouse models of cancer, including CDX and/or PDX xenograft models is preferred.</li><li>Familiarity with data analysis, presentation, data management, and statistical software (e.g. Microsoft Office, Study Director, GraphPad Prism) is a plus.</li><li>Grounding in ADC or TCE therapeutics is desired.</li></ul><p><strong>Key Leadership Competencies</strong></p><ul><li>Builds strong relationships with peers and cross-functionally with partners outside the team to enable higher performance.</li><li>Learns quickly and changes course when indicated.</li><li>Raises the bar and is never satisfied with the status quo.</li><li>Embraces others' ideas, nurtures innovation and brings it to reality.</li></ul>",
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          "text": "<p><strong>About AbbVie</strong></p><p>AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at&#xa0;<a href=\"http://www.abbvie.com/\" rel=\"noopener noreferrer\">www.abbvie.com</a>. Follow @abbvie on&#xa0;<a href=\"https://www.linkedin.com/company/abbvie/\" rel=\"noopener noreferrer\">LinkedIn,</a>&#xa0;<a href=\"https://www.facebook.com/AbbVieGlobal/\" rel=\"noopener noreferrer\">Facebook</a>,&#xa0;<a href=\"https://www.instagram.com/abbvie/\" rel=\"noopener noreferrer\">Instagram</a>,&#xa0;<a href=\"https://twitter.com/abbvie\" rel=\"noopener noreferrer\">X</a>&#xa0;and&#xa0;<a href=\"https://www.youtube.com/user/AbbVie\" rel=\"noopener noreferrer\">YouTube.</a></p>",
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          "text": "<p>​Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or&#xa0;local law:&#xa0;​</p><ul><li>The compensation range described below is the range of possible base pay compensation that the Company&#xa0;believes in&#xa0;good faith it will pay for this role at the&#xa0;time&#xa0;of&#xa0;this posting based on the job grade for this position.&#xa0;Individual&#xa0;compensation paid within this range will depend on many factors including geographic&#xa0;location,&#xa0;and&#xa0;we&#xa0;may&#xa0;ultimately&#xa0;pay&#xa0;more or less than the posted range. This range may be&#xa0;modified&#xa0;in the&#xa0;future.&#xa0;​</li><li>We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),&#xa0;medical/dental/vision&#xa0;insurance and 401(k) to eligible&#xa0;employees.​</li><li>This job is eligible to&#xa0;participate&#xa0;in our short-term incentive&#xa0;programs.&#xa0;​</li></ul><p>Note: No amount of pay&#xa0;is considered to be&#xa0;wages or compensation until such amount is earned, vested, and&#xa0;determinable.&#xa0;The&#xa0;amount&#xa0;and&#xa0;availability&#xa0;of &#xa0;any&#xa0;bonus,&#xa0;commission, incentive, benefits, or any other form of&#xa0;compensation and benefits&#xa0;that are allocable to a particular employee&#xa0;remains&#xa0;in the Company's&#xa0;sole&#xa0;and&#xa0;absolute&#xa0;discretion unless and until paid and&#xa0;may be&#xa0;modified&#xa0;at the Company’s sole and absolute discretion, consistent with&#xa0;applicable law.&#xa0;​</p><div sr-tagline=\"\"></div><p>AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.&#xa0;</p><p>US &amp; Puerto Rico only - to learn more, visit&#xa0;<a href=\"https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html\" rel=\"noopener noreferrer\">https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html</a></p><p>US &amp; Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:</p><p><a href=\"https://www.abbvie.com/join-us/reasonable-accommodations.html\" rel=\"noopener noreferrer\">https://www.abbvie.com/join-us/reasonable-accommodations.html</a></p>",
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