Medical Director, US Medical Affairs

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook . Role Summary: The US Medical Director of Medical Affairs leads Dyne’s medical strategy and execution within the United States, focusing on launch readiness, US-specific KOL engagement, congress planning and execution, and supports real-world evidence (RWE) initiatives. This role ensures alignment with global strategy while tailoring activities to US regulatory, payer, and healthcare landscapes. This role leads efforts to communicate and disseminate scientific and clinical information, engage with medical professionals in the field and contribute to the overall success of the company’s portfolio. The US Medical Director collaborates closely with Global Medical Affairs, US Commercial, Regulatory, Market Access, and Clinical teams to drive successful product introduction and lifecycle management in the US market. This role is located in our Waltham, MA office. Primary Responsibilities Include : Develop and execute US Medical Affairs strategy aligned with global objectives and US market needs Act as point person for all US Medical Affairs launch readiness activities, including working closely with global medical director and scientific communications on development of scientific platform development, local congress planning, and local medical education programs Support congress strategy execution in the US, including booth activities, symposia, and scientific presentations Work closely and with the Head of the Medical Science Liaison (MSL) team on US KOL engagement strategy: identify, map, and build relationships with key US experts Support insight collection and synthesis, and supporting the development of field material, working with the MSL team Develop US Medical Affairs advisory board strategy and organize and execute advisory boards and expert panels Work collaboratively with HCP and Patient Marketing as well as cross-functional stakeholders to integrate medical perspectives into brand strategy, ensuring alignment with scientific and commercial objectives Partner with Clinical Development and Clinical Operations to support US trial site engagement and recruitment strategies Working with the Global Medical Director, identify opportunities to generate real-world evidence (RWE) and phase IV data to address data gaps and support HCP and payer treatment decisions Ensure compliance with US regulatory and legal requirements for all medical activities Serve as subject matter expert on neuromuscular diseases and Dyne’s therapeutic platforms for US stakeholders Support the review and approval of externally presented materials through the Medical Review committee and Promotional Review Committee Act as a role model for integrity and compliance in all interactions Education and Skills Requirements : Doctorate degree (MD, PhD, PharmD) with experience in rare diseases; neuromuscular experience preferred Minimum 8 years of relevant experience in Medical Affairs within the US pharmaceutical/biotech industry Proven ability to lead US launch readiness and medical strategy execution Excellent communication and relationship-building skills with US KOLs and cross-functional teams Ability to interpret and communicate complex scientific data to diverse audiences Effective communication skills (written, verbal and presentation) Must be willing to travel up to 30%, inclusive of overnight and occasional weekends to meet with customers, internal stakeholders and attend relevant conferences Candidates must be authorized to work in the U.S. Positive team member who embodies Dyne’s Core Values Excitement about Dyne’s vision and mission Experience managing direct reports MA Pay Range $196,000 — $285,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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