Senior Research Associate, In Vivo Discovery

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    "description": "<p><span style=\"font-size: 12pt; font-weight: bold\">Senior Research Associate, In Vivo Discovery</span></p>\n<p><span style=\"font-size: 12pt\"><span style=\"font-weight: bold\">Location: </span>Boston, MA</span></p>\n<p><span style=\"font-size: 12pt\"><span style=\"font-weight: bold\">Reports to: </span>Principal Scientist</span></p>\n<p><span style=\"font-size: 12pt\"><span style=\"font-weight: bold\">Job Type:</span> Full-Time, Onsite</span></p>\n<p><span style=\"font-size: 12pt\"> </span></p>\n<p><span style=\"font-size: 12pt\">About Us</span></p>\n<p><span style=\"font-size: 12pt\">We are an innovative, stealth-mode biotech company developing in vivo gene editing therapeutics with a focus on targeted delivery of CRISPR machinery to therapeutically relevant cell types.</span></p>\n<p><span style=\"font-size: 12pt\"> </span></p>\n<p><span style=\"font-size: 12pt\">Job Summary</span></p>\n<p><span style=\"font-size: 12pt\">The Translational Research team is hiring a Senior Research Associate to lead the cellular and molecular characterization of delivery and editing platforms supporting our preclinical programs. This is a hands-on bench role with significant ownership of experimental design, execution, and data interpretation. The location for this position is onsite, 5 days per week, in our Boston lab.</span></p>\n<p><span style=\"font-size: 12pt\"> </span></p>\n<p><span style=\"font-size: 12pt\">Responsibilities</span></p>\n<ul>\n<li><span style=\"font-size: 12pt\">Design, develop, and qualify molecular assays to measure CRISPR editing outcomes in vitro and in vivo, including amplicon NGS for indel quantification, TIDE/ICE, ddPCR, and orthogonal confirmation methods.</span></li>\n<li><span style=\"font-size: 12pt\">Lead cell-based pharmacology assays evaluating delivery efficiency, editing efficiency, and on-target activity of LNP- and antibody-based delivery platforms.</span></li>\n<li><span style=\"font-size: 12pt\">Plan and execute in vivo studies in mice evaluating biodistribution, editing efficiency, and pharmacodynamic activity; analyze tissues for nucleic acid and protein endpoints.</span></li>\n<li><span style=\"font-size: 12pt\">Extract and purify RNA, DNA, and protein from cultured cells and animal tissues; run downstream analytical workflows (qPCR, RT-qPCR, Sanger and NGS sequencing, ddPCR, Western blot or Jess, ELISA, flow cytometry).</span></li>\n<li><span style=\"font-size: 12pt\">Maintain primary and immortalized mammalian cell lines using aseptic technique; perform transfection and electroporation of CRISPR reagents.</span></li>\n<li><span style=\"font-size: 12pt\">Analyze experimental data, interpret results in the context of program goals, and present findings in team meetings and written reports.</span></li>\n<li><span style=\"font-size: 12pt\">Contribute to study design, protocol development, and SOPs. Mentor junior research associates and support cross-functional collaboration with Delivery, Editing, and Translational teams.</span></li>\n<li><span style=\"font-size: 12pt\">Maintain rigorous electronic and paper lab records consistent with reproducibility and data integrity standards.</span></li>\n</ul>\n<p><span style=\"font-size: 12pt\"> </span></p>\n<p><span style=\"font-size: 12pt\">Qualifications</span></p>\n<ul>\n<li><span style=\"font-size: 12pt\">BS with 6+ years or MS with 4+ years of hands-on research experience in molecular and cell biology in industry or academia.</span></li>\n<li><span style=\"font-size: 12pt\">Direct experience with CRISPR gene editing, including assay readouts for editing efficiency (amplicon NGS, TIDE/ICE, or equivalent).</span></li>\n<li><span style=\"font-size: 12pt\">Demonstrated expertise in mammalian cell culture and design, execution, and troubleshooting of cell-based assays.</span></li>\n<li><span style=\"font-size: 12pt\">Strong working knowledge of core molecular and analytical methods: PCR, RT-qPCR, Sanger and NGS sequencing, SDS-PAGE / Western blot (or Jess capillary electrophoresis), ELISA, and flow cytometry.</span></li>\n<li><span style=\"font-size: 12pt\">Mammalian cell culture, cell transfection, and sterile techniques.</span></li>\n<li><span style=\"font-size: 12pt\">Experience designing and executing in vivo rodent studies, including tissue collection and downstream analysis.</span></li>\n<li><span style=\"font-size: 12pt\">Ability to independently scope, plan, and execute experiments with minimal supervision; track record of contributing to project decisions based on data.</span></li>\n<li><span style=\"font-size: 12pt\">Clear written and verbal communication; comfortable presenting data to a scientific audience.</span></li>\n<li><span style=\"font-size: 12pt\">Authorization to work in the United States without current or future sponsorship required.</span></li>\n</ul>\n<p><span style=\"font-size: 12pt\"> </span></p>\n<p><span style=\"font-size: 12pt\">Preferred Qualifications</span></p>\n<ul>\n<li><span style=\"font-size: 12pt\">Hands-on experience with hematopoietic stem cells (HSCs / HSPCs), including isolation, ex vivo expansion, and multilineage differentiation assays (CFU, erythroid, myeloid).</span></li>\n<li><span style=\"font-size: 12pt\">Experience with LNP-based delivery of nucleic acids, including formulation handling, dose preparation, and in vivo administration.</span></li>\n<li><span style=\"font-size: 12pt\">Experience with antibody-based or receptor-targeted delivery strategies.</span></li>\n<li><span style=\"font-size: 12pt\">Familiarity with bioinformatics tools for amplicon sequencing analysis (e.g., CRISPResso, CRISPRessoBatch).</span></li>\n<li><span style=\"font-size: 12pt\">Prior experience supporting IND-enabling or GLP studies.</span></li>\n</ul>\n<p><span style=\"font-size: 12pt\"> </span></p>\n<p><span style=\"font-size: 12pt\">Benefits</span></p>\n<ul>\n<li><span style=\"font-size: 12pt\">Competitive salary, equity, and comprehensive benefits package.</span></li>\n<li><span style=\"font-size: 12pt\">Opportunities for professional growth and leadership development.</span></li>\n<li><span style=\"font-size: 12pt\">Fast-paced, collaborative, and innovative work environment.</span></li>\n<li><span style=\"font-size: 12pt\">We offer an exceptional benefits package to include Medical, Dental, Vision, Life, Disability, a 401k Match of 4%, Paid Time Off and Equity.</span></li>\n</ul>\n<p><span style=\"font-size: 12pt\"> </span></p>\n<p><span style=\"font-size: 12pt\">How to Apply</span></p>\n<p><span style=\"font-size: 12pt\">Interested candidates should submit their resume and a cover letter detailing relevant experience. To be considered for the role, applicants must be:</span></p>\n<ul>\n<li><span style=\"font-size: 12pt\">Eligible to work in the United States for any employer without sponsorship.</span></li>\n<li><span style=\"font-size: 12pt\">Able to work onsite in the lab located in San Diego.</span></li>\n<li><span style=\"font-size: 12pt\">A direct candidate and not from a third party, i.e., staffing agency.</span></li>\n</ul>\n<p><br><br></p>\n<p><span style=\"font-size: 12pt\">Equal Opportunity Employer</span></p>\n<p><span style=\"font-size: 12pt\">We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. All employment decisions are based on business needs, job requirements, and individual qualifications, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.</span></p>\n<p><span style=\"font-size: 12pt\"> </span></p>\n<p><span style=\"font-size: 12pt\">Salary Range</span></p>\n<p><span style=\"font-size: 12pt\">$90,000 - $120,000</span></p>",
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