Manager, R&D Finance

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale. Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges. Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX. Together we are moving psychiatry forward—beyond better, into a boundless future. Join us! Reporting to the Director, Finance, the Manager, R&D Finance will support end‑to‑end financial management of the Company’s research and development activities, with a primary focus on clinical trial accounting, accruals, budgeting, and financial controls. This role will be responsible for ensuring the timely and accurate preparation of R&D‑related accounting data, specifically site payments and accruals, and will partner closely with the Clinical Operations and Development teams to provide financial insight, support decision‑making, and maintain strong internal controls. The Manager, R&D Finance will play a key role in monthly close activities, clinical expense forecasting, audit support, and process improvement initiatives, while collaborating cross‑functionally with Clinical Operations, Legal, Procurement, FP&A, and external vendors. Responsibilities: Clinical & R&D Accounting Prepare and review month‑end accruals related to clinical trials, CROs, sites, and other R&D vendors Maintain recurring journal entries and supporting documentation related to R&D expenses Apply accounting judgment related to the timing and recognition of clinical trial costs Prepare quarterly clinical vendor confirmations and audit support schedules Clinical Trial Financial Oversight Validate monthly site payments and partner with the Company’s site payment vendor to resolve discrepancies Review and analyze Clinical Trial Agreements (CTAs), amendments, and site budgets (including Phase 3 trials) for financial accuracy and alignment with forecasts Track clinical milestones, pass‑through costs, and vendor commitments to ensure accurate expense recognition Budgeting, Forecasting & Analysis Perform detailed monthly actual‑versus‑budget variance analysis for R&D and Clinical Operations spend Maintain rolling forecasts for clinical trial expenses and support updates based on study progress, amendments, and vendor activity Assist with the annual budget and periodic forecast processes, including scenario analysis related to clinical timelines and spend variability Cross‑Functional Partnership Serve as a key finance partner to Clinical Operations and Development teams, translating clinical activity into financial impacts Coordinate with Legal and Procurement on contract economics, payment terms, and amendments Collaborate with FP&A to align accounting data with forecasts, cash runway analyses, and management reporting Controls, Audit & Process Improvement Assist with the design, execution, and documentation of Sarbanes‑Oxley (SOX) controls related to R&D and clinical accounting Serve as a primary finance contact for internal and external audit requests related to clinical and R&D spend Identify and implement process improvements to enhance accuracy, efficiency, and scalability of R&D financial processes Other Support special projects, system enhancements, and ad hoc analyses as needed Perform other general accounting duties as assigned Minimum Qualifications Bachelor’s degree in Accounting, Finance, or related field; CPA preferred Minimum of 4 years of progressive accounting or finance experience; public company experience strongly preferred Experience supporting R&D and/or clinical trial accounting within the life sciences industry strongly preferred Demonstrated ability to apply accounting judgment in areas involving estimates, accruals, and complex contracts Experience with NetSuite or other ERP systems; advanced Excel skills required Strong analytical, organizational, and problem‑solving skills Ability to manage multiple priorities and meet deadlines in a fast‑paced environment Strong communication skills and ability to work effectively with non‑finance stakeholders The starting base pay range for this position is $111,365.00 - $135,356.00. Compensation will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location. Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including: 100% paid health benefits including Medical, Dental and Vision for you and your dependents 401(k) program with company match and vesting after the turn of the first month after your start date Flexible time off Generous parental leave and some fun fringe perks!

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