Associate Scientist II, CMC Analytical Development

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position This position is in the Analytical Development (AD) Group within the CMC Manufacturing Organization. An Associate Scientist II will support method development/validation activities for new drug substances and drug product. The Associate Scientist II will also support testing required for GLP Toxicology and cGMP Clinical Trial material release, as well as stability studies. This position reports to either AD Management, or Senior AD staff. Responsibilities Know and adhere to cGMP policies and procedures and relevant SOPs Work closely with team members to provide accurate analytical results in support of new and on-going projects Work with supervision to meet project timelines and deliverables Perform testing of samples to support batch release and stability studies Perform portions of analytical techniques, such as HPLC, GC, FTIR, UV/Vis, LC/MS, KF, etc. Assist with the design and initiation for development of analytical methods and improvement of existing ones to support all stages of drug development process Handle, analyze and characterize chemicals, pharmaceuticals, and related organic molecules Evaluate and interpret scientific data and provide the significance of such with supervision Assist in the design and execution of non-routine experiments Analyze data/results and interpret outcome of experiments and propose appropriate follow-up for straightforward studies Compile data tables of results, certificate of analysis, and develop stability reports Write analytical test methods and protocols Calibrate, maintain, and troubleshoot simple and some complex analytical equipment Other duties as assigned Requirements B.S in Chemistry (or related area of study) At least 3 years of experience working in a chemistry laboratory setting Familiar with analytical instrumentation, test methodology/validations, data acquisition systems, and cGMP policies and practices. Ability to correctly analyze data/results and interpret outcome of experiments and to propose appropriate follow-up. Strong attention to detail. Works well with others and in a team environment Flexible with changing priorities Wisconsin pay range $65,000 — $78,000 USD Arrowhead provides competitive salaries and an excellent benefit package. Candidates must have current, valid authorization to work in the country where this role is located. California Applicant Privacy Policy

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  "title": "Associate Scientist II, CMC Analytical Development",
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