Senior Medical Director

“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com . Follow Mineralys on LinkedIn, Twitter and Bluesky” Mineralys is a fully remote company. Position Summary The Senior Medical Director will serve as a strategic and scientific leader responsible for shaping and executing the global medical affairs strategy in support of the company’s pipeline and future commercial products. This physician leader will bridge Clinical Development and Commercial, ensuring scientific integrity, evidence generation, and external engagement across key stakeholders. This role will oversee Health Economics and Outcomes Research (HEOR) and Strategic Alliances & External Engagement and will play a critical role in preparing the organization for regulatory milestones and commercialization. Key Responsibilities Medical Strategy & Leadership Develop and lead the global Medical Affairs strategy aligned with clinical development plans and commercial objectives Serve as a key medical voice in cross-functional leadership discussions, including Clinical, Regulatory, Commercial, and Market Access Translate clinical and scientific data into impactful medical strategies that support product differentiation and value demonstration Scientific Engagement & External Leadership Build and maintain relationships with Key Opinion Leaders (KOLs), academic institutions, and clinical investigators Represent the company at scientific congresses, advisory boards, and external forums Lead and support advisory board strategy and execution Provide strategic oversight of HEOR, including real-world evidence (RWE), outcomes research, and value-based evidence generation Develop and oversee the global strategy for corporate sponsorships, grants, and charitable contributions in alignment with medical and scientific priorities Lead team in identifying and building relationships with key patient organizations Provide scientific insights for the development of economic models, burden-of-disease studies, and comparative effectiveness research Cross-Functional Collaboration Partner closely with Clinical Development on trial design, investigator engagement, and data interpretation Collaborate with Commercial and Market Access teams to ensure scientific alignment and appropriate support of launch readiness Contribute to regulatory strategy and interactions, as needed Launch Readiness Play a leadership role in preparing for first product launch, including scientific platform development and field medical readiness Ensure generation and communication of data supporting product value proposition Qualifications MD or DO required Cardiovascular experience preferred 8+ years of experience in the pharmaceutical or biotechnology industry, including significant Medical Affairs leadership experience Demonstrated experience in HEOR / RWE strategy and execution Experience supporting late-stage development and/or product launches Proven ability to lead cross-functional initiatives and influence senior stakeholders Strong external presence with experience engaging KOLs and representing company at scientific forums Travel This position requires up to 30% travel. Frequently travel is outside the local area and overnight. This position is eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level. US Salary Range: $330,000-$364,000 #LI-Remote

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