Scientist I, Quality Control

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position This position is within the Quality Control structure, under the Quality Organization. A Scientist I, Quality Control will support the analytical testing of Environmental monitoring samples, pharmaceutical raw materials, in­ process manufacturing samples, finished drug substances and drug product, and/or stability sample testing activities for new drug substances and drug products. The Senior Scientist I will also support testing required for GLP Toxicology and cGMP Clinical Trial material release, as well as stability studies. The Senior Scientist I is expected to be proficient in several analytical techniques and will be capable of making independent scientific decisions. The position also requires the ability to lead and mentor co-workers. This position reports to QC Laboratory Management. Responsibilities Fully knowledgeable of cGMP requirements and ICH guidelines Works independently to meet project timelines and deliverables with minimal supervision to no supervision Collaborates routinely with Analytical Development on procedural method transfers and may participate in the execution of method validation protocols Performs routine analytical testing of pharmaceutical raw materials, in-process samples, finished products and stability samples using established test methods and procedures Proficient with various analytical instrumentation theory and practice Executes training requirements for assigned SOPs and participates in department specific training modules. Independently completes complex instrumentation for testing according to written test methods and procedural documents to analyze samples Demonstrates proficiency with a variety of instrumentation (e.g., HPLC, GC, LC-MS, KF, FTIR, Endotoxin plate readers, and/or Raman spectroscopy) and will assist in training on instrumentation as Is a subject matter expert in technical aspects of both instrumentation and workflow management and prioritization Performs analyses in a timely and efficient manner to support ongoing prioritized studies Works closely with other department personnel for efficient project execution and timely/accurate deliverables while building a relationship with respect and communication Trains and mentors co-workers (analysts) Shows initiative and interest in mastering new techniques and tests Ability to track/trend data and interpret degrative changes to the product on stability Uses stability tracking software as a repository generated results (data entry, review and approval). Owns and leads scientific technical discussions and brainstorming sessions Identifies and troubleshoots analytical method issues with instrumentation, general chemistry, test methodology and sample product Communicates laboratory testing issues or challenges to laboratory management Maintains a clear, concise, and accurate notebook Performs technical data review on data acquired by other QC analysts as applicable Drafts technical documents such as COAs, investigations, deviations, and CAPAs Possesses excellent written and verbal communication skills Embraces cGMP and ICH requirements for all associated work Works cooperatively in a team environment Demonstrates a high attention to detail Calibration, maintenance, and troubleshooting of analytical equipment with little to no guidance from management Routinely makes sound, scientific decisions independently and serves as a back-up to Laboratory Management Demonstrates enduring flexibility and understanding with changing priorities. Requirements M.S. in Chemistry (or related field) with 7+ years relevant laboratory experience B.S. in Chemistry (or related field) with 9+ years of relevant laboratory experience Fully knowledgeable of cGMP and ICH laboratory requirements and operations Proficient and demonstrated experience with analytical instrumentation, test methodology/validations/transfers, data acquisition systems, and typical cGMP policies/practices Wisconsin pay range $90,000 — $108,000 USD Arrowhead provides competitive salaries and an excellent benefit package. Candidates must have current, valid authorization to work in the country where this role is located. California Applicant Privacy Policy

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  "title": "Scientist I, Quality Control",
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