Associate Director, Health Economics & Outcomes Research/Real-World Evidence (HEOR/RWE)

“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com . Follow Mineralys on LinkedIn, Twitter and Bluesky” Mineralys is a fully remote company. Position Summary: The Associate Director, HEOR / Real-World Evidence (RWE) plays a strategic and scientific leadership role in developing and executing evidence strategies that support the clinical and economic value of our innovative therapy. This position is responsible for designing and delivering real-world and outcomes research evidence to support medical affairs, market access, and regulatory objectives. The role focuses on generating high-quality, decision-relevant evidence, including observational studies, external control arms, and economic models, and indirect treatment comparisons, to contextualize clinical outcomes, demonstrate value, and support stakeholder decision- making. The Associate Director collaborates cross-functionally with Medical Affairs, biostatistics, and commercial teams, while also engaging external partners such as academic researchers, key opinion leaders, and data vendors. This role contributes to strategic evidence planning, scientific communication, and advancing real-world data capabilities within a matrixed organization. Key Responsibilities: Lead the design, execution, and oversight of HEOR and RWE studies, including observational studies (retrospective/prospective cohorts), economic models, external control arms and indirect treatment comparisons. Oversee data analysis ensuring methodological rigor and contribute to research reports for internal and external consumption. Develop and execute integrated HEOR strategies aligned with product development and market access needs. Identify evidence gaps and define research strategies to address unmet needs, burden of disease, and treatment pathways. Support development of value messaging tools (e.g., cost-effectiveness models, budget impact models). Cross-functional Collaboration & Stakeholder Engagement Partner cross-functionally with Medical Affairs, Clinical Development, Market Value & Access and Commercial teams to align with data needs. Build and manage relationships with external experts, academic collaborators, and vendors. Provide HEOR/RWE expertise to support interactions with HTA agencies. Lead publication planning and development of HEOR/RWE abstracts, manuscripts, and presentations for scientific congresses and peer-reviewed journals. Operational Leadership & Governance Oversee vendor selection and management, ensuring timely, high-quality study execution. Manage timelines, budgets, and deliverables across multiple projects Ensure all HEOR activities adhere to compliance guidelines, internal SOPs, regulatory standards, and ethical guidelines for RWD and economic modeling. Qualifications: Advanced degree required (PhD, PharmD, MD, MPH, or similar) in health economics, outcomes research, biostatistics, epidemiology or related field. Minimum of 8 years of relevant experience in HEOR, RWE, or outcomes research in pharmaceutical, biotech, consulting, or academic settings. Strong analytical skills and strong understanding of observational study design, real-world data sources (claims, EMR, registries), and health economic modeling. Experience with burden of illness studies, and comparative effectiveness research. Familiarity HTA requirements and RWE regulatory landscape. Demonstrated ability to successfully lead complex research projects independently and collaboratively. Strong communication, and scientific writing skills, including publication track record. Proven cross-functional collaboration and stakeholder engagement capabilities. Travel: This position requires up to 20% travel. Frequently travel is outside the local area and overnight. US Salary Range: $175,000 - $200,000 #LI-Remote

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  "title": "Associate Director, Health Economics & Outcomes Research/Real-World Evidence (HEOR/RWE)",
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      "value": "“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone.  Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor.  Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky”\n\nMineralys is a fully remote company.",
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      "value": "This position is eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level. US Salary Range:",
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