Scientist II - Manager, PD Upstream

Forge Your Future with Us: At Forge Biologics, we believe in turning bold ideas into life-changing realities. Our mission is simple yet powerful: to enable access to life-changing gene therapies and help bring them from ideas into reality. We partner with scientists, physicians, biotech and pharma innovators, and patient communities — all united by one goal: improving lives. If you’re driven by purpose and excited to make a tangible impact, this is where your journey begins. Our team works out of The Hearth, a state-of-the-art, 200,000-square-foot cGMP facility in Columbus, Ohio. Here, you won’t just watch innovation happen — you’ll be part of it. Whether you’re scaling AAV manufacturing, collaborating on cutting-edge therapies, or supporting complex technical projects, you’ll play a key role in bringing hope to patients with genetic diseases. What sets Forge apart is our culture of H.O.P.E. We are hardworking , showing up each day with determination and grit. We are open , creating a space where ideas flow freely, and every voice is valued. We are purpose-driven , with every task directly tied to changing lives. And we are engaged , energized by the challenges we face and the milestones we achieve together. At Forge, your growth matters. We’re committed to helping you expand your skills, take on new challenges, and develop your career through mentorship, hands-on learning, and opportunities for advancement. Our people are our greatest investment, and we’re proud to see team members grow with us. If you’re ready to use your talent to help deliver hope to patients around the world, join us — and be part of something bigger than yourself. About The Role: The Scientist II provides active leadership and execution of the laboratory experiments and protocols for upstream process development efforts. This individual will lead projects and complex experiments, train junior scientists, and actively contribute to the advancement of AAV manufacturing processes. Responsibilities: Senior-level technical contributor and subject matter expert for upstream systems and process strategy Independently manages multiple projects or client programs simultaneously, maintaining a high degree of quality, scientific rigor, and compliance Leads process development activities for early- to late-stage programs, including scale-up, technology transfer, and validation support Designs and executes complex DoE studies, authors technical reports, and contributes to regulatory documentation Anticipates challenges in upstream scale-up and proactively develops solutions to ensure technical success Acts as a key liaison between Process Development, Manufacturing, and Quality teams to align on strategy and ensure smooth GMP execution Contributes scientific rationale for tech transfer packages and GMP documentation without owning official SOPs or batch records Mentors junior scientists and associates through day-to-day technical guidance, fostering development in experimental design, documentation standards, and scientific reasoning Qualifications: Bachelor’s Degree in Chemical Engineering , Bio e ngineering, Biology, or related discipline (or equivalent experience) Working knowledge of cell culture techniques utilizing mammalian cells Proven ability to operate and troubleshoot bioreactors Experience planning, conducting and reviewing experimental data with minimal oversight E xperience training and development of other team members Experience analyzing data sets and utilizing the corresponding data to influence decision making E xperience working with external collaborators (clients, external technology transfers, etc. ) P roject management experience Preferred Skills: Master’s Degree or PhD in Chemical Engineering, Bio e ngineering, Biology, or related discipline (or equivalent experience) Experience working with viral vectors (AAV, Lentivirus, etc.) This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee. Duties, responsibilities and activities may change or new ones may be assigned. Work Environment and Physical Demands This position works in both a laboratory environment and typical office environment where the physical work demands will vary depending on the specific tasks and duties required of the job. The employee will be stationary (standing/sitting) for extended periods of time. Employees regularly wear personal protective equipment based on the task being performed. Must be able to work in a confined space, such as a clean room or laboratory environment. Ability to identify small details within the field of vision, distinguish between different colors, and accurately identify objects within a specific area. Forge Biologics is an equal opportunity employer dedicated to building an inclusive and diverse workforce.  Forge Biologics, provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. We’ve Got You Covered: At Forge Biologics, we believe our people deserve to be taken care of – in and out of the workplace. We’ve built a comprehensive compensation and benefits package designed to help you thrive, grow, and feel valued every step of the way: Health from day one Health, dental and vision insurance start your first day – with 90% of premiums covered for you and your family. Time to recharge A competitive paid time off plan – because rest fuels innovation. 12 weeks of fully paid parental leave so you can focus on family when it matters most. Rewarding your impact Annual bonus opportunities for all full-time team members. 401(k) with company match to help you plan for the future . Special employee discounts, including childcare and dependent care savings. Your wellness, supported Onsite fitness facility at The Hearth. Mental health counseling and financial planning services through our Employee Assistance Program. Employer-paid short and long-term disability coverage to protect your peace of mind. Fuel for your workday A fully stocked kitchen with free snacks and beverages – we keep you energized and ready for what’s next. Grow with us Ongoing professional development resources, training, and mentorship programs to help you build your care and grow within Forge.

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  "title": "Scientist II - Manager, PD Upstream",
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