Executive Director, Portfolio Management

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: We are looking for a highly motivated individual with experience in portfolio management, decision analysis and a passion for developing solutions for complex problems to build out this cross-functional capability and help shape our portfolio strategy. This position will report to the SVP, Development Management and Program Leadership and will be based at our headquarters in Redwood City, CA. In this highly cross functional role, you will be expected to evolve the wider portfolio management capability within Revolution Medicines and closely collaborate with Portfolio Working Group, Disease Area Teams, Program Teams, Life Cycle Teams, Analytics and Insights, Finance, Commercial and many other relevant functions. You must be entrepreneurial, able to “roll up their sleeves” and thrive in a fast-paced, highly cross-functional environment. You are an exceptional strategic and critical thinker, have a passion for interpreting and analyzing complex data, and have strong interpersonal skills that you will leverage to successfully partner cross-functionally with internal teams and senior stakeholders. Create and deliver robust Revolution Medicine portfolio strategies that provide the scaffolding for molecule decisions. Actively manage the Revolution Medicine portfolio with an enterprise mindset, providing data-driven actionable portfolio insights that contextualize individual molecule and project decisions. Identify current and future needs and evolve capabilities to remain fit for purpose as our portfolio continues to increase in complexity. Implement best practices including development and use of qualitative and quantitative methods for portfolio prioritization, decision analysis, project trade-offs, and assigning probability of success to support decision making. Drive the development and collation of R&D inputs for program and portfolio evaluations, including target product profiles, development plans and probability of success assessment, and ensure consistency with financial and commercial inputs. Serve as an active thought partner to decision-makers and closely work with Program Teams, Life Cycle Teams and relevant functions on areas including, but not limited to defining/scoping of tactics to deliver on defined portfolio strategies; content expertise to develop strategic options and valuations; trade-off analysis, and/or decision framing including portfolio context; application of analytical tools and frameworks to clearly present options and solutions to optimize the portfolio. Maintain a detailed understanding of the shape and drivers of the portfolio through proactive involvement with key stakeholders and assess impact of external developments on our portfolio. Lead and manage other high impact projects that arise outside of regular portfolio planning cycles, ensuring that these one-off initiatives are aligned to overall business objectives. Contribute to the overall strategy and development of Development Management and Program Leadership. Uphold an open, inclusive and collaborative culture with a focus on shared learning and people development. Required Skills, Experience, and Education: 15+ years' experience in the biotech/pharmaceutical industry with 5+ years' experience in portfolio management, portfolio planning or similar function(s). Intensive experience with clinical development stages and understanding of the external landscape and key players in the Oncology space. Strong insight into strategic and commercial drivers of the pharmaceutical market with a thorough understanding of the drug development and commercialization process. Exceptional analytical and problem-solving skills, with the ability to interpret complex data, and present it in a clear and concise manner. Proficiency in utilizing data to drive strategic decision making and portfolio optimization. Proven ability to think strategically with sound judgment and decision-making. Demonstrated leadership, influencing skills, critical thinking, creativity, and ability to manage complexity and operate amidst ambiguity. Excellent interpersonal skills and the ability to build and maintain positive work relationships to effectively interface at all levels across the organization. Demonstrated ability to lead cross-functional teams and drive results in a dynamic and fast-paced environment. Preferred Skills: A. or BSc. in Life Sciences with a MSc, MBA or Ph.D. Line management experience preferred, matrix management experience acceptable alternative. #LI-Hybrid #LI-GL1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy . For additional information, please contact [email protected] . Base Pay Salary Range $265,000 — $331,000 USD We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to [email protected] so we can share these impersonations with our IT team for tracking and awareness.

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