Senior Scientist/Principal Investigator-BioAnalytical Services

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    "requisitionDescription": "<div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><link href=\"https://cdn.jsdelivr.net/npm/[email protected]/css/froala_editor.pkgd.min.css\" rel=\"stylesheet\" type=\"text/css\">&nbsp;<link href=\"https://cdn.jsdelivr.net/npm/[email protected]/css/froala_style.min.css\" rel=\"stylesheet\" type=\"text/css\"><div class=\"fr-view\"><main style='box-sizing: inherit; min-height: 39.6vh; padding-bottom: 60px; color: rgb(68, 68, 68); font-family: \"Franklin Gothic Book\", \"Century Gothic\", CenturyGothic, AppleGothic, sans-serif; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;'><div style=\"box-sizing: inherit; margin: 0px auto; padding: 0px 0.9375rem; border: 0px; font: inherit; vertical-align: baseline; max-width: 72.5rem; position: relative;\"><div style=\"box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font: inherit; vertical-align: baseline; display: flex; zoom: 1; flex-wrap: wrap; position: relative; width: 1130px; max-width: 100%; list-style-type: none; letter-spacing: -0.31em !important; word-spacing: -0.43em !important;\"><article style=\"box-sizing: border-box; margin: 0px; padding: 0px; border: 0px; font: inherit; vertical-align: top; display: flex; zoom: 1; flex-direction: column; letter-spacing: normal; word-spacing: normal; white-space: normal; position: relative; width: 1130px; flex-shrink: 0;\"><div style=\"box-sizing: border-box; margin: 0px; padding: 0px; border: 0px; font: inherit; vertical-align: baseline;\"><div style=\"box-sizing: border-box; margin: 0px; padding: 0px; border: 0px; font: inherit; vertical-align: baseline;\"><p style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Aptos\",sans-serif;' data-pasted=\"true\"><strong>Scientist/ Senior Scientist/ Principal Scientist, method Developer, Large Molecules Quantitation by LC-MS/MS, Bioanalytical Services</strong></p><p style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Aptos\",sans-serif;'>Location: Exton, PA (Corporate)</p><p style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Aptos\",sans-serif;'>Full time</p><p style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Aptos\",sans-serif;'><strong><u>Responsibilities</u></strong>:</p><ul style=\"margin-bottom:0in;margin-top:0in;\" type=\"disc\"><li style=\"margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family: initial;\">Mainly responsible for developing bioanalytical quantitation methods for large molecules, such as peptides, protein biomarkers, Oligos, mAbs, ADCs or sugar, lipids, etc in biological matrices using LC-MS/MS platform with triple quadrupole MS and with HRMS.</li><li style=\"margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family: initial;\">Directly working with method development team head to design the experimental activities to address the bioanalytical challenges of the method, conduct the experiments, summarize the method development results, discussion with the team head of the experimental results and present the results internally and to sponsors.</li><li style=\"margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family: initial;\">Simultaneously handle multiple method development projects or method qualification/method validation as required. Coordinate study activities with supervisor and internal team to ensure efficiency and quality of the projects within the timeline.</li><li style=\"margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family: initial;\">Coordinate with internal team, like PI and PMs, to deliver the established methods to internal team for method validation and sample analysis within the expected timeline. Provide technical support and troubleshooting in cases the method performance does not meet the expectation.</li><li style=\"margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family: initial;\">Keep track of industry trending on the quantitation of large molecules using LC-MS platform. Assess, evaluate and implement new technologies or instruments in the GLP labs to improve the analysis efficiency or data quality.</li><li style=\"margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family: initial;\">Set-up, utilize, and maintain complex instrumentation Follow safety precautions</li></ul><p style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Aptos\",sans-serif;'><strong><u>Education and Requirements</u></strong>:</p><ul style=\"margin-bottom:0in;margin-top:0in;\" type=\"disc\"><li style=\"margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family: initial;\">Prior working experience working large molecules, such as peptides, Oligos, mAbs, ADCs or sugar, lipids, etc in the regulated BioA lab for at least 1 year experience.</li><li style=\"margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family: initial;\">Prior working experience in LC-triple quadrupole MS. The experience with HRMS is a plus. Experience with Sciex QTOF instrument and/or Thermo Orbitrap Exploris HRMS is an additional plus. The experience with microflow or nanoflow LC is a plus.</li><li style=\"margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family: initial;\">Prior experience developing and validating bio-analytical methods for the quantitation of small molecules and large molecules in biological matrices using LC-MS/MS platform in a GLP lab.</li><li style=\"margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family: initial;\">Experience using Sciex Analyst software, OS software, and Thermo Chromeleon and Watson LIMS is a plus</li><li style=\"margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family: initial;\">Proven ability to successfully work in a team environment. Excellent oral and written communication skills. Understanding of experimental design and planning, data collection and summarize the experimental results and presentation skills, and familiar with common data analysis software</li><li style=\"margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family: initial;\">Ph.D. in Analytical Chemistry, Biochemistry, Pharmacology or related scientific discipline with 1-2+ years direct experience, OR Master&rsquo;s degree in same disciplines with 2-4+ years direct experience in large molecules quantitation field using LC-MS/MS platform, OR Bachelor&rsquo;s degree in same discipline with 5+ years direct experience in large molecules quantitation field using LC-MS/MS platform.</li></ul><p style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Aptos\",sans-serif;'><strong><u>Salary and Benefits</u>:</strong></p><p style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Aptos\",sans-serif;'>Frontage Laboratories offers a competitive compensation and generous benefits package including health and dental insurance, a 401(k) plan, health insurance, short and long-term disability insurance, life insurance etc.</p><p style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:115%;font-size:16px;font-family:\"Aptos\",sans-serif;'><em>Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.</em></p></div></div></article></div></div></main><footer style='box-sizing: inherit; margin: 0px; padding: 5px 0px; border-width: 1px 0px 0px; border-top-style: solid; border-right-style: initial; border-bottom-style: initial; border-left-style: initial; border-top-color: rgb(217, 217, 217); border-right-color: initial; border-bottom-color: initial; border-left-color: initial; border-image: initial; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-weight: 400; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: Foco, sans-serif; vertical-align: baseline; display: block; background: url(\"/wp-content/uploads/2020/04/Frontage_wave-1.png\") center bottom no-repeat rgb(255, 255, 255); position: relative; z-index: 99; color: rgb(68, 68, 68); letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;'><div style=\"box-sizing: inherit; margin: 0px auto; padding: 0px 0.9375rem; border: 0px; font: inherit; vertical-align: baseline; max-width: 72.5rem; position: relative;\"><br></div></footer></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>\n",
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