Director, HEOR

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale. Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges. Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX. Together we are moving psychiatry forward—beyond better, into a boundless future. Join us! We are seeking a Director of Health Economics & Outcomes Research (HEOR) to support the development and implementation of innovative and strategically focused value evidence generation activities supporting the clinical development, commercialization, and access of Definium products in therapeutic area of brain health disorders. The candidate is responsible for designing and developing research projects, conducting analysis, reporting and publication of HEOR studies, and providing methodologic input to the clinical development needs (where warranted) throughout the product lifecycle. Experience in executing real-world and prospective studies and patient-centered outcomes assessments (PCOA) is preferred. The role will report to the Senior Director, HEOR. While the focus is for the U.S. market, the candidate may be called upon to work across different time zones at times. The successful candidate is driven, self-sufficient, curious, collaborative, with a bold ambition to contribute to ground-breaking drug development with potential to transform brain health diseases with very high unmet medical need. She/he is a generous collaborator with innovative approaches, and a willingness to learn new concepts while working in a fast-growing, dynamic environment. Responsibilities: Leads the design, implementation and management of HEOR studies from concept development through publication. HEOR studies may include, but are not limited to, prospective research studies, patient interviews, and payer-focused tools (i.e. dossier, external facing assets) Help identify evidence gaps and needs from regulatory, reimbursement and patient perspectives, resolve these challenges and translate strategic objectives into the HEOR / Real-World Evidence (RWE) plan Directs the generation of necessary evidence to demonstrate product differentiation and values, and / or to support clinical development, regulatory needs through RWE and epidemiology studies in a timely and strategic manner Work closely with other functions in cultivating strong internal partnerships, including research and development strategy, epidemiology, regulatory, policy, market access and medical affairs on the development on programs that support broad access and value Support proactive engagement with payer advisors and KOL stakeholders including generating strategic insights on endpoints, PCOA, and trial design. Identify relevant PCOA endpoints and provide input to the clinical development plan Psychometric validation of patient-reported outcomes and instruments Help develop protocols for RWE (prospective and retrospective) analyses, PROs, surveys/patient interviews and provide innovative solutions on RWE for use as a synthetic/historical or concurrent control, including expertise on methodological considerations to account for confounding, missing variable, temporal or other biases and/or methodological challenges Experience in evidence synthesis (in conducting systematic literature review, indirect treatment comparisons, gap analyses for effectiveness, meta-analysis) Collaborate with Publications and other functions on development of real-world evidence publications for congresses and peer-reviewed journals Provide project and vendor management support, including request for proposal, statement of work, vendor selection, legal & compliance issues, and budget tracking Develop and maintain strong, collaborative relationships with the broader Definium organization and with external experts Help support and manage deliverables such as value dossiers, reimbursement dossiers, reimbursement landscape analyses, consultant driven research projects Ensure that deliverables are accomplished on time and within budget Requirements: Advanced degree (MS, MPH, MD, PhD, PharmD) in health economics, epidemiology, health services research Minimum 5-7 years’ experience in HEOR in an industry setting, preferably in psychiatry or neuroscience related therapeutic areas Excellent knowledge of market access environment and health technology assessment process in the U.S. and key European markets Demonstrated experience in designing HEOR protocol elements both within phase III / non-interventional study programs and phase IV/post-marketing Previous new product launch experience a plus Demonstrated business and scientific acumen Excellent analytic and problem-solving skills Demonstrated ability to understand and effectively communicate scientific information Ability to work independently, proven oral and written communication skills Ability to work effectively in a fast-paced, collaborative environment Aptitude to closely collaborate and bond with an entirely remote team, willing to travel on a regular basis for in-person team meetings (projected ~25% – 30% travel) The starting base pay range for this position is $227,109.00 - $255,000.00. Compensation will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location. Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including: 100% paid health benefits including Medical, Dental and Vision for you and your dependents 401(k) program with company match and vesting after the turn of the first month after your start date Flexible time off Generous parental leave and some fun fringe perks!

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