Scientist II, ADC/AOC Conjugation

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          "text": "<p><strong>Key Responsibilities:</strong></p><ul><li>Synthesis, purification, and characterization of antibody drug conjugates (ADCs) and antibody oligonucleotide conjugates (AOCs) on mg to gram scale under minimal supervision.</li><li>Development, optimization, and validation of conjugation protocols specifically for antibody oligonucleotide conjugates.</li><li>Optimization and validation of formulation buffers for bioconjugates.</li><li>Lead application and refinement of automated techniques for ADC/AOC synthesis and purification.</li><li>Collaboration with cross-functional teams to advance ADC/AOC discovery programs from conceptualization to early development.</li></ul>",
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          "text": "<p><strong>Qualifications</strong></p><ul><li>B.S. degree with 7 years of experience or M.S. degree with 5 years’ experience in Biochemistry, Organic, Bioorganic or Analytical Chemistry, Molecular Biology, or related field.</li><li>Demonstrated hands-on expertise in laboratory-scale protein purification using Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), mixed-mode chromatography, and/or affinity chromatography. Experience with GE AKTA FPLC and Unicorn software is preferred.</li><li>Hands-on experience with relevant analytical techniques such as HIC-HPLC, SEC, IEX, RP-HPLC, LCMS and capillary electrophoresis techniques (e.g., CE-SDS, icIEF).</li><li>Strong experience in the discovery, design, synthesis, and purification of antibody drug conjugates (ADCs) and antibody oligonucleotide conjugates (AOC), including familiarity with associated chemistry and analytical methods.</li><li>Proven ability to independently design experiments, troubleshoot technical issues, and deliver high-quality scientific output with attention to detail, and the ability to thrive in a fast-paced, cross-disciplinary team environment.</li><li>Excellent written and oral communication skills, with a strong record of collaboration and innovation.</li></ul><p><strong>Preferred:</strong></p><ul><li>Previous experience with linker chemistry and payload conjugation strategies specific to oligonucleotide therapeutics.</li><li>Experience troubleshooting or optimizing the stability and delivery of antibody-oligonucleotide conjugates.</li></ul>",
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          "text": "<p><strong>About AbbVie</strong></p><p>AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at&#xa0;<a href=\"http://www.abbvie.com/\" rel=\"noopener noreferrer\">www.abbvie.com</a>. Follow @abbvie on&#xa0;<a href=\"https://www.linkedin.com/company/abbvie/\" rel=\"noopener noreferrer\">LinkedIn,</a>&#xa0;<a href=\"https://www.facebook.com/AbbVieGlobal/\" rel=\"noopener noreferrer\">Facebook</a>,&#xa0;<a href=\"https://www.instagram.com/abbvie/\" rel=\"noopener noreferrer\">Instagram</a>,&#xa0;<a href=\"https://twitter.com/abbvie\" rel=\"noopener noreferrer\">X</a>&#xa0;and&#xa0;<a href=\"https://www.youtube.com/user/AbbVie\" rel=\"noopener noreferrer\">YouTube.</a></p>",
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