Senior Program Manager

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: This is an exciting opportunity to advance first-in-Class RAS(ON) Inhibitors through clinical development. The ideal candidate is a strategic program management professional with deep experience leading cross-functional Companion Diagnostics (CDx) development activities supporting targeted oncology therapies. This individual will drive alignment across internal functions and external diagnostic partners to enable successful clinical development, regulatory execution, and commercialization readiness. The successful candidate will draw on their experience to: Lead cross-functional Companion Diagnostics development programs supporting clinical-stage oncology assets from assay strategy through clinical and regulatory execution. Work closely with CDx Leads and other clinical development team members to facilitate science-based CDx decision making and drive the execution of the CDx development strategy. Develop and maintain integrated cross-functional program plans, timelines, milestones, dependencies, and critical path analyses across internal teams and external diagnostic partners. Drive cross-functional alignment and coordinate CDx operational activities across Translational Medicine, Clinical Development, Regulatory Affairs, Biomarker Sciences, Clinical Operations, Alliance Management, and external diagnostics partners and vendors. Proactively identify program risks, resource constraints, and operational bottlenecks, and lead mitigation planning to ensure program execution and delivery. Facilitate program governance activities, including preparation of executive-level updates, program status reporting, risk escalation, and decision tracking. Partner with diagnostic partners and vendors and study teams to monitor execution against timelines, deliverables, and key milestones. Lead implementation of program management best practices, operational processes, and scalable planning tools to support growing Companion Diagnostics capabilities. Oversee implementation of clinical trial assays at reference labs and centralized testing vendors. Support strategic planning activities related to Companion Diagnostics portfolio execution, regulatory readiness, and commercialization planning. Influence cross-functional teams through data-driven recommendations, transparent communication, and structured problem-solving. Required Skills, Experience and Education: B.A. or BSc. In Life Sciences with 8+ years of biotechnology, pharmaceutical, diagnostics, or clinical development experience, including 5+ years leading cross-functional drug development or Companion Diagnostics programs. Strong understanding of oncology drug development, biomarker strategy, assay development, clinical validation, and companion diagnostics regulatory pathways. Demonstrated success in leading complex cross-functional initiatives in matrixed environments with internal and external stakeholders. Strong strategic planning, risk management, and program governance skills. Ability to influence stakeholders and drive alignment across multiple functions and organizational levels. Excellent communication and executive presentation skills with the ability to synthesize complex information into actionable recommendations. Experience developing integrated timelines, managing dependencies, and driving execution across multiple workstreams. Strong motivation, attention to detail, ability to think independently and fully integrate into a high achieving team environment. Highly proficient using MS Office, Lucid Charts and Project Management software to manage project timelines and resources (e.g. MS Project, Smartsheet, Office Timeline, etc.). Preferred Skills: MSc., MBA or advanced degree in related field preferred. Experience managing Companion Diagnostics or biomarker-driven development programs. PMP (Project Management Professional) or other PM certification or equivalent. Experience in Oncology therapeutic area and clinical stages of drug development. #LI-Hybrid #LI-EM1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy . For additional information, please contact [email protected] . Base Pay Salary Range $164,000 — $205,000 USD We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to [email protected] so we can share these impersonations with our IT team for tracking and awareness.

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