Senior Scientist, LNP Formulation & Process Development

nChroma Bio is a clinical-stage genetic medicines company developing engineered epigenetic silencers to overcome the limitations of existing therapies and enable next-generation genomic medicines. By combining in vivo delivery and gene-regulating technologies, nChroma is designing optimal solutions to deliver precise, potent and durable treatments for patients with high unmet needs. nChroma’s lead candidate, CRMA-1001, is a clinical-stage, liver-directed epigenetic silencer in development as a potential functional cure for chronic hepatitis B. Guided by a world-class team at the forefront of genetic medicine, founded by renowned pioneers in the field, and supported by top-tier investors, nChroma is redefining targeted in vivo genetic medicine with the initial goal of treating diseases affecting the liver, blood, cardiovascular and central nervous systems. We’re building a culture and organization to support this important mission, bringing together individuals that thrive in a supportive environment where diverse perspectives and a passion for discovery drive cutting-edge science and breakthrough medicines. ABOUT THE ROLE The Sr. Scientist LNP Formulation & Process Development will contribute to the development and optimization of nChroma’s Lipid Nanoparticle (LNP) formulations and collaborate with both internal research teams and external CROs/CDMOs to support multiple programs spanning early research and development. RESPONSIBILITIES Leverage both internal team and external CROs to optimize and produce high quality LNPs to support efforts spanning early research and development. Provide SME support for external production with our CDMO partners. Lead from the bench and contribute to a high-performing Formulation & PD team, including initiating excellent laboratory and documentation practices, and providing mentorship and development opportunities for junior team members. Contribute as CMC representative for GMP production support & regulatory filings as needed. Collaborate with key stakeholders from research, drug substance, analytical development, pharmacology and other internal functions to support program, department, and corporate goals. SKILLS & COMPETENCIES: Hands on experience with LNP formulation including optimization, conjugation, scale-up. Direct managerial experience. Excellent analytical, problem solving and critical thinking skills, including an ability to combine attention to detail with a big picture perspective. Strong oral and written communication skills with experience presenting scientific research. Ability to thrive in a fast-paced, innovative, and, at times, uncertain or changing environment while remaining flexible, proactive, and resourceful. Adept at prioritizing and managing multiple tasks simultaneously, integrating cross-functional issues, and balancing competing priorities effectively. Collaborative and team-oriented mindset with a desire to positively impact culture. QUALIFICATIONS: 4-5 years in the biopharmaceutical industry with a proven track record with nucleic acids delivery, LNP formulation and scale up, including tech transfer to GMP suites. Advanced degree in Chemistry, Biophysics, Biochemistry, Bioengineering, or related life sciences with strong scientific background. Preferred in-depth experience with analytical assays for LNP characterization. Experience providing guidance and mentorship to junior scientists. Experience supporting development programs, including communicating between CMC and Program Teams. The salary range for this role is $145K - $175K nChroma Bio is an equal opportunity employer, providing equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, nChroma Bio complies with applicable state and local laws governing nondiscrimination in employment.

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