Scientist, Mechanistic Biology

tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate mechanistic biologist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced mechanistic biologist to join our Discovery Biology Team. In this position, you will work closely with our Platform and Chemistry Teams to drive mechanistic understanding of our lead compounds and support core drug discovery efforts. This is an opportunity to help elucidate novel pharmacological mechanisms of our next-gen IPMs. Your responsibilities will include designing and executing mechanistic studies on hit compounds, dissecting signaling pathways to map compound mechanism of action, interrogating protein-protein interactions, preparing and analyzing NGS libraries, and developing and deploying functional cell-based assays to characterize novel pharmacology. About You High Agency. Initiative, independence, and self-accountability are some of our most valued traits. Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team. Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way. Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too. Qualifications & Nice-To-Haves BS, MS or PhD in Cell Biology, Biochemistry, or related field. Candidates without a PhD should have 5-7+ years of relevant industry experience. Previous experience elucidating novel biology underlying small-molecule mechanism of action in a drug discovery context. Top-notch written and oral communication skills. Strong experience with : Cellular and molecular biology, including extensive experience with mammalian cell line work and associated assays, stable cell line generation (lentiviral and CRISPR-based systems), co-IP/pull-down assays, RNA-seq, global proteomics, flow cytometry, plasmid design/cloning, etc. Small molecule drug development campaigns (hit discovery, hit validation, dose-response studies, SAR and MOA studies) Mechanistic studies of cell signaling, pathway analysis, and PTM analysis Protein-protein interaction techniques (e.g., BRET, APEX/BioID, AlphaScreen, etc.) NGS library prep, sequencing, and analysis Nice to have: Experience with PROTAC/next-gen IPM technologies Experience working at the interface of mechanistic biology and chemistry Experience working on teams that have successfully advanced research to the clinic Experience managing CROs Benefits Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly. Top tier medical, dental, and vision coverage + One Medical membership. 401(k) retirement plans. Education and health/fitness incentive programs. Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days. Reading budget! We will buy you books. 📚 Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés. About Us Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴 Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews. Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few. Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing. Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :) More info at jobs.generalproximity.bio

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