Senior Scientist, LNP Sciences

Company Overview: Beam Therapeutics is a biotechnology company committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform with integrated gene editing, delivery and internal manufacturing capabilities. Beam’s suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases. Position Overview: Beam is seeking a scientist with expertise in formulation and ligand conjugation. The candidate will work on formulation, ligand conjugation, and scale-up of lipid nanoparticles (LNPs) targeting different organs and cell types. They will work as part of a team to develop drug products with the goal of bringing in vivo base editing to patients. We are looking for an ambitious candidate who wants to grow within the LNP Sciences group. This candidate will help shape the LNP platform and grow with the aspirations of the organization as we advance into later stages of development. Primary Responsibilities: Responsible for formulation design, development, characterization, and technology transfer to enable development of Beam sterile drug products. Accountable as an individual contributor to support formulation development as well as providing necessary guidance and support of drug product control strategy for drug candidates across all stages of development. Independently design, execute, analyze, and document experiments to optimize LNP potency, tolerability, biodistribution, and ligand conjugation. Design and execute experiments to enable a robust and reproducible process for manufacture of ligand conjugated LNPs at-scale. Interface closely with Analytical Development and Biotherapeutics teams to characterize different unit operations for the manufacturing of DP to understand process robustness. Provide support with tech transfer activities for manufacturing of drug products. Generate high quality documentation as per Beam SOPs and in support of regulatory filings. Communicate scientifically rigorous findings via verbal and written communications, and presentations both internally and externally. Qualifications: PhD or MS in Pharmaceutical Sciences, Chemical Engineering, Bioengineering or related field with drug product and CMC development experience (PhD 4+ years or MS 12+ years). Deep understanding of sterile product development. Prior industry research experience, especially in nucleic acids and drug delivery, is required. Experience with development of antibody-drug conjugates and/or biologics is preferred. Knowledge of statistical techniques and concepts (regression, properties of distributions, statistical tests, and proper usage, etc.). Ability to adapt to increasing scope and complexity of work brought on by growth/change and help others manage through change. A successful candidate will have excellent computational, written, and verbal communication skills, strong organizational abilities, and an ability to work with a diverse group of scientists and engineers. Ability to work in a hybrid environment with sufficient on-site presence. The salary range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, education, scope of job, internal comparisons, and market data. Beam Pay Range $145,000 — $180,000 USD

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