Integrated Safety Analysis (ISA) Engineer

About the Company General Matter is enriching uranium in America. Our goal is to design, build, and operate the world’s lowest-cost enrichment services in the United States. Our mission is to restore America’s ability to produce nuclear fuel—fuel that will power AI, advanced manufacturing, critical industries, and the next generation of nuclear reactors. Ultimately, our work will help power national ambitions and enable a high-energy society. We were incubated by Founders Fund, like Anduril and Palantir before us, and are backed by top-tier investors. Our lean, world-class team of engineers and operators is applying a first-principles approach to solving the problem of nuclear fuel production. We are a mission-driven company with a culture of urgency, accountability, and transparency. Help us build a high-energy society by making the cleanest, safest form of baseload energy the most affordable. About This Role We are seeking a highly skilled Integrated Safety Analysis (ISA) Engineer to support the design, licensing, and operation of a new Nuclear Regulatory Commission (NRC)–licensed fuel enrichment facility regulated under 10 CFR Part 70. In this role, you will be a key contributor to ensuring that plant processes meet regulatory requirements for nuclear criticality safety, chemical safety, fire protection, and overall facility risk management. The ideal candidate has experience working in nuclear or high-hazard industries, strong analytical skills, and a deep understanding of risk-informed safety methodologies. Responsibilities Lead and support development of Integrated Safety Analyses (ISAs) in accordance with 10 CFR Part 70 Subpart H, including hazard identification, accident sequence modeling, and consequence analysis. Perform and document process hazard analyses (PHAs) using techniques such as HAZOP, What-If, and FMEA. Develop, evaluate, and maintain items relied on for safety (IROFS) and associated safety controls. Work closely with engineering, operations, and regulatory teams to ensure plant design, modifications, and procedures remain compliant with NRC licensing basis. Develop and maintain ISA Summary documentation, safety basis changes, and supporting technical analyses. Support NRC interactions, including audits, inspections, and technical review responses Conduct risk assessments related to nuclear criticality safety, chemical hazards, fire protection, and facility natural phenomena hazards. Participate in configuration management, change reviews, and design verification for modifications impacting the facility safety basis Provide technical expertise to support startup, commissioning, and operational readiness activities. Basic Qualifications Bachelor’s degree in Chemical Engineering, Mechanical Engineering, Nuclear Engineering, or a related field. Advanced degrees (MS, MBA, or PhD) may substitute for up to 2-3 years of experience, depending on the degree level. 4+ years of experience in experience in nuclear safety, process safety, or similar high-hazard environments. Familiarity with safety analysis methodologies, for example: Process Hazard Analysis (PHA) Criticality Safety Analysis (CSA) Fire Hazard Analysis (FHA) External Hazard Analysis (EHA) Strong analytical and problem-solving abilities, with attention to detail. Excellent communication skills, both written and verbal, for conveying technical safety data to diverse audiences. Ability to work collaboratively across engineering, operations, and licensing teams. Preferred Skills and Experience Evidence of exceptional ability (prior projects, portfolio of work, completed products, etc). Experience in a fast-paced engineering environment or a highly technical role requiring a resourceful, entrepreneurial approach to complete tasks within tight timeframes or budget constraints. Experience with IROFS, ISA, ISA Summaries, Safety Analysis Reports (SAR), HAZOP, and Risk Determination. 8+ years of experience in nuclear safety, process safety, or similar high hazard environments. Direct experience with the NRC 10CFR70 license application process. Familiarity with NRC safety standards and relevant regulatory frameworks. Knowledge or experience with vacuum systems, cryogenics, compressible flow, or nuclear chemical processes. In lieu of nuclear related experience, a strong preference will be given to candidates with petrochemical ISA engineering experience. Additional Requirements Ability to work extended hours and weekends as necessary. Equal Opportunity Employer General Matter is an Equal Opportunity Employer; employment with General Matter is governed on the basis of merit, competence and qualifications and will not be influenced in any manner by race, color, religion, gender, national origin/ethnicity, veteran status, disability status, age, sexual orientation, gender identity, marital status, mental or physical disability or any other legally protected status. Compensation and Benefits The base salary range for this role is $100,000–$200,000 annually. Compensation bands are determined by role, level, location, and alignment with market data. Individual level and base pay is determined on a case-by-case basis and may vary based on job-related skills, education, experience, technical capabilities and internal equity. Please note that the stated salary range is an estimate and may be adjusted based on market conditions, business needs, or other factors. In addition to base salary, for full-time hires, you may also be eligible for long-term incentives, in the form of stock options, and access to medical, vision & dental coverage as well as access to a 401(k) retirement plan.

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