Senior/Principal Scientist IHC

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    "description": "<p><span style=\"font-weight: bold\"><span><span>About Oxford BioTherapeutics</span></span></span><span> </span></p>\n<p><span><span>Oxford Biotherapeutics is a clinical-stage biotechnology company focusing </span><span>on  the</span><span> development of antibody therapeutics for the treatment of cancer. OBT’s OGAP-verify® platform is the world's largest, cancer specific, membrane protein library, directly measuring plasma membrane protein expression in patient tumors. OGAP is used to </span><span>identify</span><span> novel, highly tumor specific antigens for novel first-in-class ADC, T-cell Engager (TCE</span><span>)</span><span> and Chimeric Antigen Receptor (CAR-T) targets.  Our lead asset, OBT076, is an Antibody Drug Conjugate (ADC) in Phase 1b clinical development.  Our clinical and pre-clinical pipeline of novel biologics is balanced between internal programs, focused on ADCs and checkpoint regulators, and externally partnered programs with key innovators in oncology such as Roche, GSK, </span><span>and Zymeworks. </span></span><span> </span></p>\n<p><span><span>For further information, please</span><span><span> </span>s</span><span>ee</span><span><span> </span></span></span><a href=\"http://www.oxfordbiotherapeutics.com/\" target=\"_blank\" rel=\"noopener noreferrer\"><span><span>www.oxfordbiotherapeutics.com</span></span></a><span> </span></p>\n<p><span> </span></p>\n<p><span style=\"font-weight: bold\"><span><span>Job Description</span></span></span><span> </span></p>\n<p><span style=\"font-size: 12pt\">We are seeking a motivated Sr. or Principal Scientist to join the Histopathology Lab within the Target Validation team in San Jose, CA. The role involves independently designing, troubleshooting, and executing histopathology workflows to evaluate oncology targets, and presenting findings to teams and partners.</span></p>\n<p><span style=\"font-size: 12pt\">You will support target validation through IHC, IF, ISH, slide scanning, image analysis, and assay optimization, with a strong focus on IHC assay development, antibody screening, tissue processing (FFPE/FF), sectioning, and tissue-based assay implementation. Hands-on histology and oncology knowledge is required.</span></p>\n<p><span> </span></p>\n<p><span> </span><span style=\"font-weight: bold\"><span><span>Responsibilities will include, but are not limited to, the following:</span></span></span><span> </span></p>\n<ul>\n<li><span style=\"font-size: 12pt\">Design and optimize chromogenic IHC assays using FFPE/FF samples; confirm specificity using orthogonal methods (e.g., ISH).</span></li>\n<li><span style=\"font-size: 12pt\">Lead histopathology support for cancer target programs, including materials management, hands-on lab work, mentorship of junior staff, and timeline delivery.</span></li>\n<li><span style=\"font-size: 12pt\">Present results, gather feedback, and implement next steps.</span></li>\n<li><span style=\"font-size: 12pt\">Use literature and public datasets to guide assay development and target validation.</span></li>\n<li><span style=\"font-size: 12pt\">Process tissues and cell pellets into FFPE/frozen blocks; section and stain samples using Leica Bond autostainers.</span></li>\n<li><span style=\"font-size: 12pt\">Digitize slides, analyze results, and document data in ELN and presentations.</span></li>\n<li><span style=\"font-size: 12pt\">Perform routine lab tasks: sample archiving, equipment maintenance, consumables ordering, logistics.</span></li>\n<li><span style=\"font-size: 12pt\">Support tissue database and digital data organization.</span></li>\n</ul>\n<p><span style=\"font-size: 12pt\"> </span></p>\n<p><span style=\"font-weight: bold\"><span><span> </span><span>R</span><span>equire</span><span>d Qualifications and Skills</span><span>:</span></span></span><span> </span></p>\n<ul>\n<li><span><span>PhD</span><span><span> </span></span><span>+</span><span>4</span><span><span> </span>years</span><span>,</span><span><span> </span></span><span>or<span> </span></span><span>Master</span><span>’</span><span>s</span><span><span> </span></span><span>+</span><span>6</span><span><span> </span>years</span><span>,</span><span><span> </span>or<span> </span></span><span>B</span><span>achelor</span><span>’</span><span>s</span><span><span> </span>+</span><span>8</span><span><span> </span>years<span> </span></span><span>or more<span> </span></span><span>of<span> </span></span><span>hands-on </span><span>experience </span><span>working </span><span>in </span><span>histology<span> </span></span><span>and</span><span><span> </span></span><span>IHC<span> </span></span><span>related</span><span><span> </span></span><span>lab</span><span>s</span><span>, preferably</span><span><span> </span></span><span>supporting</span><span><span> </span>cancer research<span> </span></span><span>in an<span> </span></span><span>industry setting.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Extensive</span><span><span> </span>(&gt;3 years)<span> </span></span><span>hands-on<span> </span></span><span>experience<span> </span></span><span>developing</span><span>,<span> </span></span><span>utilizing</span><span>, and interpreting </span><span>immunohistochemistry </span><span>assays</span><span><span> </span></span><span>against</span><span><span> </span>novel protein targets</span><span>,<span> </span></span><span>using both<span> </span></span><span>single</span><span><span> </span>and multiplex</span><span><span> </span>IHC techniques</span><span><span> </span>primarily on FFPE sample slides</span><span>.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Extensive</span><span><span> </span></span><span>(&gt;3 years)<span> </span></span><span>hands-on<span> </span></span><span>experience in<span> </span></span><span>laboratory<span> </span></span><span>histology,<span> </span></span><span>including preparation o</span><span>f<span> </span></span><span>tissue sample</span><span>s</span><span><span> </span></span><span>into FFPE and FF blocks</span><span>,<span> </span></span><span>preparation of<span> </span></span><span>cell pellet control blocks,<span> </span></span><span>cryostat</span><span><span> </span>and microtome </span><span>sectioning</span><span>, </span><span>troubleshooting<span> </span></span><span>chromogenic<span> </span></span><span>IHC</span><span><span> </span>and</span><br><span>ISH</span><span><span> </span>experiments</span><span>, and<span> </span></span><span>indep</span><span>endently<span> </span></span><span>identifying<span> </span></span><span>appropriate<span> </span></span><span>next</span><span><span> </span>steps in the development of<span> </span></span><span>robust,<span> </span></span><span>sensitive</span><span><span> </span>and specific tissue biomarker assays.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>E</span><span>xperience with<span> </span></span><span>Leica Bond<span> </span></span><span>autostainers</span><span><span> </span>and reagents</span><span><span> </span></span><span>relevant to </span><span>optimiz</span><span>ing </span><span>new </span><span>IHC </span><span>assays</span><span>, </span><span>typically </span><span>chromogenic<span> </span></span><span>assays</span><span>.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Experience with<span> </span></span><span>microscop</span><span>e<span> </span></span><span>slide scanners</span><span><span> </span>for<span> </span></span><span>b</span><span>righ</span><span>tf</span><span>ield and<span> </span></span><span>f</span><span>luorescent</span><span><span> </span>imaging, and</span><span><span> </span></span><span>general experience </span><span>utilizing</span><span><span> </span>whole-slide<span> </span></span><span>image analysis software</span><span><span> </span>such as HALO</span><span>.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Collaborate effectively in a matrix-managed organization to drive advancement of early-stage projects into translational and clinical<span> </span></span><span>development</span><span>.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Be relied upon as a technical expert in the IHC field</span><span>;</span><span><span> </span>provide guidance to colleagues and collaborators, and mentorship to more junior lab colleagues</span><span>.</span></span><span> </span></li>\n</ul>\n<p><span style=\"font-weight: bold\"><span><span>Preferred</span><span><span> </span>Qualifications and Skills:</span></span></span><span> </span></p>\n<ul>\n<li><span><span>K</span><span>nowledge<span> </span></span><span>in</span><span><span> </span>cancer biology</span><span>,</span><span><span> </span>immuno-oncology</span><span>, and<span> </span></span><span>tumor<span> </span></span><span>histo</span><span>pathology</span><span><span> </span></span><span>are</span><span><span> </span></span><span>each<span> </span></span><span>a plus</span><span>.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Strong<span> </span></span><span>track record</span><span><span> </span>of developing and implementing strategic initiatives to improve scientific and/or operational activities.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Relevant e</span><span>xperience working with service providers and CROs</span><span><span> </span>in the histology space.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Excellent organization skills</span><span>,</span><span><span> </span>and<span> </span></span><span>evidence of<span> </span></span><span>previous</span><span><span> </span>success</span><span><span> </span></span><span>in</span><span><span> </span></span><span>a<span> </span></span><span>growing and<span> </span></span><span>fast-paced</span><span><span> </span>work<span> </span></span><span>environment.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Experience<span> </span></span><span>regularly<span> </span></span><span>presenting<span> </span></span><span>IHC assay<span> </span></span><span>results in group settings.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Top candidates will be</span><span><span> </span></span><span>collaborative and team</span><span><span> </span>oriented</span><span>,</span><span><span> </span></span><span>c</span><span>reative problem solver</span><span>s</span><span>,</span><span><span> </span></span><span>resilient to change</span><span>, </span><span>and </span><span>interested in learning<span> </span></span><span>opportunities</span><span>.</span></span><span> </span></li>\n</ul>\n<ul>\n<li><span><span>Experience with<span> </span></span><span>cell culture and<span> </span></span><span>related<span> </span></span><span>molecular biology<span> </span></span><span>assays (WB/ELISA/etc.)<span> </span></span><span>are<span> </span></span><span>additionally</span><span><span> </span>a plus.</span></span><span> </span></li>\n</ul>\n<p><br><br></p>\n<p><span style=\"font-weight: bold\">Benefits Offered:</span></p>\n<ul>\n<li>Medical, dental and vision insurance for employee and dependents</li>\n<li>FSA (Flexible Spending Account)</li>\n<li>STD, LTD, Basic Life and AD&amp;D Insurance, Supplemental Life </li>\n<li>401(k) Plan</li>\n<li>120 hours of Paid Time Off</li>\n<li>5 sick days per year</li>\n<li>11 holidays</li>\n<li>Employee Referral Bonus Program</li>\n<li>Annual bonus program</li>\n<li>New hire stock options</li>\n</ul>\n<p><br><br></p>\n<p><span style=\"font-weight: bold\">Equal Opportunities Statement</span></p>\n<p><span>OBT is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status. All qualified applicants will receive consideration for employment. One of our top priorities is to maintain the health and wellbeing of our employees and their families. To achieve this goal, we offer comprehensive benefits.</span></p>",
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