Senior Manager, Supply Chain Planner

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values: *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. *MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: Vaxcyte is seeking a strategic and execution-focused Senior Manager, Supply Chain Planner to join our Supply Chain Planning Team. This role is responsible for leading end-to-end supply planning across clinical and commercial programs, including demand and supply planning, capacity management, inventory strategy, and scenario analysis. The ideal candidate brings deep experience in biotech supply chains, strong systems and analytical capabilities, and a proven ability to translate complex data into actionable plans. This individual will play a critical role in driving cross-functional alignment, scaling planning processes and systems, and ensuring reliable supply to support Vaxcyte’s growth and commercialization objectives. Essential Functions: Lead end-to-end supply planning processes, including demand, supply, capacity, and inventory planning, ensuring alignment with business objectives Develop integrated production and material plans using OMP Unison Planning System in collaboration with internal functions, CMOs, and suppliers Facilitate monthly demand and supply reviews within the S&OP process to align cross-functional stakeholders and enable informed decision-making Continuously improve planning processes, OMP Unison Planning system capabilities, and SOPs to enhance planning accuracy, efficiency, and scalability Build and maintain complex planning models, ensuring comprehensive system parameters and master data to support OMP and ERP integration Define and execute inventory strategies across raw materials, intermediates, and finished goods to balance service, cost, and expiry risk Lead scenario planning and “what-if” analyses to proactively identify risks and opportunities and implement mitigation strategies Monitor supply performance across CMOs to enable high-quality product delivery per plan Develop, track, and communicate KPIs to provide actionable insights and support data-driven decisions Cultivate strong cross-functional and external partnerships to enable effective planning, communication, and execution Requirements: B.S./B.A. required; advanced degree (MBA, MS, or equivalent) preferred 8+ years of progressive supply chain planning experience in biotechnology, pharmaceuticals, or a related regulated industry Deep expertise in end-to-end supply planning, including demand, supply, capacity planning, and inventory optimization Hands-on experience with advanced planning systems (APS), preferably OMP Unison Planning, including implementation and process design Drive exceptional accuracy, precision, and data integrity across all planning activities, with a clear understanding of the substantial financial impact of supply decisions Proven experience leading S&OP processes and driving cross-functional alignment Strong analytical and data modeling skills; advanced Excel required, experience with planning or visualization tools preferred Experience with external manufacturing networks in a GMP environment Demonstrated ability to lead scenario planning and risk mitigation to ensure continuity of supply Strong leadership and influencing skills, with the ability to align diverse stakeholders and drive execution Excellent communication and executive presentation skills Highly organized, with the ability to manage multiple priorities in a fast-paced, evolving environment Detail-oriented with a continuous improvement mindset and focus on operational excellence Reports to: Senior Director, Supply Planning Location: San Carlos, CA Work Arrangement: Hybrid (minimum of 2-3 days per week) Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. Salary Range: $176,000 - $205,000 (SF Bay Area). Salary ranges for non-California locations may vary. Relocation: This role is not eligible for relocation assistance. #LI-JN1 We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.

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